DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and slc22a31

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_012817743.1	Gene:	slc22a31 / 100485676	XenbaseID:	XB-GENE-6048942	Length:	558	Species:	Xenopus tropicalis

Alignment Length:	582	Identity:	114/582 - (19%)
Similarity:	189/582 - (32%)	Gaps:	220/582 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 MGNFGPWQLRSLLILFLCKIPAAW-FMACILFTAPDLYPEEEYKCDTTAFGPDVNSTVSLDHCYV 129
            :|.||.:........:|..:..|. |.:.:::||     ...|:|          ..||.|.|..
Frog    11 VGGFGRYTRLLAAATWLPNVALAMGFFSELMYTA-----VPSYQC----------QGVSGDPCPG 60

  Fly   130 MVNYGESAYAMRQCRKFLYTTGFH---------SLTMEFDLVCLCD-----------FFVAWSQY 174
            ..::..|:...:.|     ..|:|         ::..:::|  |||           :.|.|
Frog    61 NSSWENSSNQSQHC-----PGGWHFQAQGWLNSNIVTQWEL--LCDRQWKVPLEKISYLVGW--- 115

  Fly   175 WHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLVKDFS--------LHCGL-RCLA 230
              |.|.:|.|....:|.|        |......|:.:|.:|:...|:        |..|. ..||
Frog   116 --LLGYIIFGCICDRLGR--------RAAFIGALVMALPLGVAVTFTSSYFSFLPLRAGFGAALA 170

  Fly   231 AVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLV 295
            .:...|.|:.     .::.:...|:...::...||..|.:||||:|.....|:.:...:|.:|::
Frog   171 GMFLSFYISR-----VELCSPSQRLMVTMIGGFFWVAGELLLPGMAVLCSDWRVLQGSITGTLML 230

  Fly   296 I-VFLLPWT--PDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKELPQQLEELRE--R 355
            : |:....|  |:||||.|     |...:|:....|...||.||  ..:.::...|.....|  .
Frog   231 LGVYWCGHTLYPESPRWLL-----ATQQVEQCKSELHMFARANG--INIGEDASGQDHVFTEIDS 288

  Fly   356 MLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVNTGLLLHVRSFGREHLVSNTLAMGLAEM 420
            :.|..|           |...:.:.::                    ||...:..|.|.:|....
Frog   289 LCEGFP-----------RPQYYSICSI--------------------FGTRLIWRNALILGFTAF 322

  Fly   421 LGC-------------------FL----------------------ALHLTFNLSERKWQWAGGF 444
            :||                   ||                      ::.|.|.:       ..||
Frog   323 IGCGIRPCFARNLQVFGPYIPYFLQAGSEIVACILICICVSHCGRRSVLLLFTI-------LTGF 380

  Fly   445 -----------------AIVVGCIGSIC--------WFLAEEDMPEVY-GLTLGLLMASLPQAAV 483
                             :||:..:||:|        .|.|.|.:|.|. |..|||:|.
Frog   381 CSLLLLALTQLDLFIEASIVISVVGSLCSHAVVMLSVFYACEVLPTVIRGSGLGLIMG------- 438

  Fly   484 ACAQSMILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVIL 545
                          :.|..|:.|.|     ..:...|..||.       .:.||:||:|.:|
Frog   439 --------------INMLGRASLPF-----IELQHKSGYFLY-------HVVLSSFCILSVL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	114/581 (20%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	32/143 (22%)
slc22a31	XP_012817743.1	MFS	110..470	CDD:119392	89/455 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910