DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and ARHGAP44

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_055674.4	Gene:	ARHGAP44 / 9912	HGNCID:	29096	Length:	818	Species:	Homo sapiens

Alignment Length:	808	Identity:	232/808 - (28%)
Similarity:	371/808 - (45%)	Gaps:	137/808 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::: :|.:.:.|:.|::....:|..:|::::..:.......:||.| |.|..|:
Human     1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             |.|||:||.....:||.|.|.:..|..|..|.|:|..|||.|..:|:.:|..||:.|..|:..|
Human    61 -EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPL 124

  Fly   129 KNILDKEIQEISTLKRNV---------SRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECE 184
            ..:.:.||..|...::::         |||..:.||  :|...:..|:...||.:.::.:.||..
Human   125 FLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTS--KSSGLSSSLQPAGAKADALREEMEEAA 187

  Fly   185 LKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQG-TEKSR 248
            .::|..||..:|.|...:|||.:..:..:..:..|..||.::|..:.|.|.:|:...:. .||..
Human   188 NRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS 252

  Fly   249 FGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPL 313
            ||..|:||||.:.|||::.:|.|...|||.|::||||.||..:::||:::|.||:...|...
Human   253 FGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQ--- 314

  Fly   314 DYQ-DPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLR 377
            :|. |||.|...||.|||||||||:|:.||.::|:.:....:.::...:.....||||.|:.|:|
Human   315 EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIR 379

  Fly   378 YLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELL 440
            ||.:|||.:.:...:|||:..|:|||:.||:|||:.:.:       |.::.::.:..|  |:|.:
Human   380 YLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGN-------ITEMMTTVSLQIVGIIEPI 437

  Fly   441 ISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTL-RRQKANAPSP 504
            |...|:||.||:||.:|          .:..:..:.|.:.|.|. |.||..... |||...|..|
Human   438 IQHADWFFPGEIEFNIT----------GNYGSPVHVNHNANYSS-MPSPDMDPADRRQPEQARRP 491

  Fly   505 ---PTTN---------------GNGI-IMTTSQTSHRPHAKELFPQQTPEKQEKPAKP-----PL 545
               .|.|               ..|: :|.|:..:.|..:........|...:.||.|     ||
Human   492 LSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPL 556

  Fly   546 PNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLK 610
            |      ||...||    |:....|.::|:           ||...|.|  :|.||..  |.:|.
Human   557 P------SPLPEQP----LDSPAAPALSPS-----------GLGLQPGP--ERTSTTK--SKELS 596

  Fly   611 PDVPQK--PLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQE-- 671
            |...||  |...:.....|. .|.|...:......:|:|...|        ::.|.|.|:.::
Human   597 PGSAQKGSPGSSQGTACAGT-QPGAQPGAQPGASPSPSQPPAD--------QSPHTLRKVSKKLA 652

  Fly   672 -------NGETNGTREVSS-TTKENNHNHDPPATAADQN----------QQQAQPQVTTPI-SPN 717
                   .|:.....:.|: .....:.:..||:|.:...          ..|..|....|: ||:
Human   653 PIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPS 717

  Fly   718 SF--------QTPK---RPTVPAPPPPT 734
            .|        .|||   |||:|.|.|||
Human   718 VFTSTLSKSRPTPKPRQRPTLPPPQPPT 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	69/240 (29%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	83/209 (40%)
ARHGAP44	NP_055674.4	BAR_Rich2	13..260	CDD:153303	70/254 (28%)
		RhoGAP	249..449	CDD:295372	83/209 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..493		10/26 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..772		58/250 (23%)
		DUF4045	<558..>674	CDD:330572	31/143 (22%)
		Interaction with BST2. /evidence=ECO:0000269\|PubMed:19273615	731..818		9/15 (60%)
		PDZ-binding	764..767
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..818
		PDZ-binding. /evidence=ECO:0000305	815..818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157321
Domainoid	1	1.000	133	1.000	Domainoid score	I5061
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3233
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm40935
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	O	PTHR14130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3388
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780