DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and AT5G19390

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_197440.2	Gene:	AT5G19390 / 832059	AraportID:	AT5G19390	Length:	870	Species:	Arabidopsis thaliana

Alignment Length:	733	Identity:	145/733 - (19%)
Similarity:	247/733 - (33%)	Gaps:	226/733 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 LIAKEDEIVSCI--------RDYVLNQRNYH---------ERAL-QHVNASL---------ARIQ 238
            ::.:||:.:..:        |.:.|....:.         |:|| |..||:|         |...
plant    81 VVVREDKKLLTVLFPDGRDGRAFTLKAETFEDLYEWKTALEQALAQAPNAALIMGQNGIFRAETN 145

  Fly   239 DTIQGTEKSRF-----GTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRM 298
            :.|:|.||...     |..:...|...:...|:: |.....:.::|.:.||:||......::.|
plant   146 EAIEGREKRPLKSLVVGRPILLALEDIDGSPSFL-EKALQFIEKYGTKIEGILRQSADVEEVER- 208

  Fly   299 KHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIK- 362
             ...|.:..||....| :||||:|..:|..|||||...::.:.....:......|:..|.:.::
plant   209 -RVQEYEQGKTEFTFD-EDPHVVGDCIKHVLRELPSSPVSASCCTALLEAYRIESKEARISSLRS 271

  Fly   363 AILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRI----------DKSS 417
            ||....|:.|...|:.:.:.:..:...|..|:|:...:|..|:|.:|.|.:          |...
plant   272 AIAETFPEPNRRLLQRILKMMHTISSHSHENRMNPNAVAACMAPLLLRPLLAGECDLEDDFDGGE 336

  Fly   418 NAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVE------GKSKSNSSNE 476
            :..|..:...|:::.|..|:.:|:..:...|..|     .:|:..:..|      |...|:..:.
plant   337 DNSAQLLAAANAANNAQAIITVLLEDYGSIFDEE-----NIQRCSISTESHIGNSGPDDSSDDDN 396

  Fly   477 NL----------------DRND----SEVMESP--------RYGTLRRQKANAPSPPTTNG---- 509
            |:                |.||    .::.||.        .|.......::..||..|||
plant   397 NMKNGYHNADNEVEPVTDDDNDRALSGKMSESSGCTGSDLYEYKGFVADDSDIESPRDTNGPRCN 461

  Fly   510 ----------NGIIMTTSQ---------------TSHRPHAKELFPQQTPEKQEKPAKPPLPNLP 549
                      |..:.:|.|               .|...|..|.: ||:......|........|
plant   462 SNIRTDHLMRNPFVNSTDQQAGEQIGDDPTKYGVNSCLAHVSESY-QQSGTGLNVPTHGNTLAAP 525

  Fly   550 QFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSF------- 607
            ..:||:|....:.          ||:. |...|..|:|     ..:|.:.|||  |||
plant   526 GLESPSAKSVNKG----------TPSS-VHAKRATFWG-----RGSARKISTD--GSFDSSGEDE 572

  Fly   608 -------------------------------------------KLKPDVP--QKPLLPKRP--TV 625
                                                       .|:.||.  |:.|..:|.  ..
plant   573 LAIQRLETTKNELRQRIAKEARGNAILQASLERRKQALHERRLSLEQDVSRLQEQLQAERDLRAA 637

  Fly   626 LGVGVPKADGKSDDEGGTTPTQATIDN---GNGSV-RFKTE-----HFLDKLRQEN-GETNGTRE 680
            |.||:..:.|:....|..:.|:|.::.   ....| |.|.:     |.|::.||.: |..:..|:
plant   638 LEVGLSMSSGQFSSHGVDSKTRAELEEIALAEADVARLKQKVAELHHQLNQQRQTHFGSFSDARD 702

  Fly   681 VSSTTKENNHNHDP---------PATAADQNQQQAQPQVTTPISP--------------NSFQTP 722
                |.:...||:|         .:|.|..|.::.|......:..              ||.| |
plant   703 ----THQYLQNHNPQKRFLQQDFDSTLAYVNHERKQRHEENVLGAEWRNSKGAGSFGVGNSRQ-P 762

  Fly   723 KRPTVPAPPPPTNWKSSD 740
            .|..:|.....|:.|.|:
plant   763 SRKQIPESTNTTDSKISE 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	17/87 (20%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	49/222 (22%)
AT5G19390	NP_197440.2	PH	19..125	CDD:278594	6/43 (14%)
		PH	19..125	CDD:214574	6/43 (14%)
		RhoGAP	176..313	CDD:279014	34/140 (24%)
		Lzipper-MIP1	610..689	CDD:291087	18/78 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I2605
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960