DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and AT5G12150

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_196776.1	Gene:	AT5G12150 / 831088	AraportID:	AT5G12150	Length:	827	Species:	Arabidopsis thaliana

Alignment Length:	685	Identity:	138/685 - (20%)
Similarity:	248/685 - (36%)	Gaps:	179/685 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 KELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKNIL-----DKEIQEISTLKRNV 146
            |..|..:| ||    .||:..|:....:.|   :.:.|||..|.:|     |.......|||
plant    53 KNDPSALP-QK----GGEVNLTLGGIDLNS---SGSVVVREDKKLLTVLFPDGRDGRAFTLK--- 106

  Fly   147 SRTLQEYTSLKRSHEAAIRLEEPAAKV---NHIKSQQEECELKLEKERDAWAAQMLELIAKEDEI 208
            :.||.:....|.:.|.|:.....||.|   |.|  .:.|....:|...::|..|.    ..:..:
plant   107 AETLDDLYEWKAALEQALAQAPNAALVIGQNGI--FRTEANNTIEASFNSWRDQR----PLKSSV 165

  Fly   209 VSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCC 273
            |.  |..:|        ||:.::.|.:.::..:|..|
plant   166 VG--RPILL--------ALEEIDGSPSFLEKALQFLE---------------------------- 192

  Fly   274 CLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEP--- 335
               .:|.:.||:||......::.|  ...|.:..||....: :||||:|..:|..||:||..
plant   193 ---TYGTKVEGILRQSADVEEVER--RVQEYEQGKTEFSPE-EDPHVVGDCVKHVLRQLPSSPVP 251

  Fly   336 -------LLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALN 393
                   |..|.:.::..|:....|         ||:...|:.|...|..:.:.:..:...|:.|
plant   252 ASCCTALLEAYKIDQNEARVNSLRS---------AIIETFPEPNRRLLLRMLKMMHTITSHSSEN 307

  Fly   394 KMSSQNLAIVMSPNMLWPRI---------DKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFI 449
            :|:|..:|..|||.:|.|.:         |...:..|..:...|:::.|..||..|:.  ||
plant   308 RMTSSAVAACMSPLLLRPLLAGECDLEGFDTLGDNSAQLLAAANAANNAQAIVTALLE--DY--- 367

  Fly   450 GEVEFYLTLQKQKLFVEGKSKSNSSN---------ENLDRNDSEVMESPRYGTLRRQKANAPSPP 505
            |.:          :..||..:.::|.         ||....:..|::.|...||..::..
plant   368 GNM----------INDEGLGRCSTSTDSHIGDSGPENSSDEEEIVVKHPDLHTLDIEEGE----- 417

  Fly   506 TTNGNGIIMTTSQTSHRPHA-KELFPQQTPEKQEKPAKPPLPNLPQFQSPAASQPTQTQL-EPLP 568
            |.:.|.::::...:....:| .:|:..:....::..|:.|.......:|...|...:..: ||:.
plant   418 TDDDNDVLLSRKPSESSDYAGSDLYDYKGFGVEDSDAESPRDIHCSVESTDFSARVKKHIEEPIK 482

  Fly   569 P--------------------PPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDV 613
            .                    |.|||:.|:...|.         :.:|::.::.:.||..:.
plant   483 DIEVSSVSPTENCYQSGREAIPSVTPSTPLTALRY---------TTSAEKPASKTTGSSTVN--- 535

  Fly   614 PQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATID-NGNGSVRF-KTEHFLDKLRQENG-ET 675
                  .||.:..|.|          .|..||.:.:.| :||..:.. :.||..|:|||... |.
plant   536 ------SKRSSSWGRG----------NGKKTPAKGSFDSSGNDELLIQRLEHMKDELRQRIAKEA 584

  Fly   676 NGTREVSSTTKENNHNHDPPATAADQNQQQAQPQV 710
            .|...:.::.:...........|.:|:..:.|.|:
plant   585 KGNAALQASLERRKQALHERRLALEQDVGRLQEQL 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	40/177 (23%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	49/225 (22%)
AT5G12150	NP_196776.1	PH	19..116	CDD:365918	20/73 (27%)
		RhoGAP	181..325	CDD:366201	39/186 (21%)
		IATP	513..611	CDD:367997	23/125 (18%)
		DUF3584	<561..>805	CDD:378817	13/59 (22%)
		Lzipper-MIP1	600..678	CDD:373041	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I2605
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960