DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Arhgap8

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006521531.1	Gene:	Arhgap8 / 73167	MGIID:	1920417	Length:	480	Species:	Mus musculus

Alignment Length:	204	Identity:	71/204 - (34%)
Similarity:	103/204 - (50%)	Gaps:	17/204 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 RFGTSLKEHLTSTNRE--ISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTP 310
            :||.|| ::|...|:.  |..::......|.|.||..|||.|...::..:|:::...:.   ..|
Mouse   247 QFGVSL-QYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTVRQVQRLYDQ---GKP 307

  Fly   311 LPL-DYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYA 374
            :.. ||.|.|:...|||.:|||||:||||:..|:..:.|....|.. |.|..:.||..||:.|||
Mouse   308 VNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYA 371

  Fly   375 NLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVEL 439
            .||||..||..|...|..|||:|.|||.|...|::|         |:..:..:::....|:..||
Mouse   372 VLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIW---------PSQGVASLSALVPLNLFTEL 427

  Fly   440 LISQWDYFF 448
            ||..:|..|
Mouse   428 LIEYYDKVF 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	4/8 (50%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	71/204 (35%)
Arhgap8	XP_006521531.1	CRAL_TRIO_2	87..220	CDD:372686
Arhgap8	XP_006521531.1	RhoGAP	248..436	CDD:383032	70/201 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920