DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and Arhgap17

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_653112.2	Gene:	Arhgap17 / 70497	MGIID:	1917747	Length:	846	Species:	Mus musculus

Alignment Length:	838	Identity:	223/838 - (26%)
Similarity:	383/838 - (45%)	Gaps:	148/838 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||::|..|.......::|.| ..|..|:
Mouse     1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.::|.||.....:||.:.|::.:|.:.: |.|:|..||:.|..:|..:.:.|:..|.:::..|
Mouse    61 -DAERRHKKLPLTALAQNMQEASAQLEESL-LGKMLETCGDAENQLALELSQHEVFVEKEIMDPL 123

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK----RSHEAA-IRLEEPAAKVNHIKSQQEECELKLE 188
            ..|.:.||..|...::.::|.:.::.|::    ::|::: ...:...:|::.:|.:.:|...|:|
Mouse   124 YGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVE 188

  Fly   189 KERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARI---QDTIQGTEKSRFG 250
            :.:|..||.|...:|||.|........:..|.:||.:||..:..:|..:   ||  :..||..||
Mouse   189 QCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQD--KWAEKPAFG 251

  Fly   251 TSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDY 315
            |.|:|||..:.|||:..:|.|...|||.|::||||.|:|..::||:::|.||:..  .:.|...|
Mouse   252 TPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCS--TSHLDEFY 314

  Fly   316 QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLT 380
            .|||.:...||.|||||||||:|::||:::.::|....:.::...:.....|||.:|:.|.|||.
Mouse   315 SDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLI 379

  Fly   381 RFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELLISQ 443
            :||:.:.|.|.:|||:..|:|||:.||:||.:.:.:       :.::.::::.::  ::|.:|..
Mouse   380 KFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGT-------LAEIAAATSVHVVAVIEPIIQH 437

  Fly   444 WDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSE-------------VMESP------ 489
            .|:||.|||||.::    :.||. .:..||::.:...|||:             |||..
Mouse   438 ADWFFPGEVEFNVS----EAFVP-LATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKES 497

  Fly   490 ------------RYGTLRRQ---KANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEK 539
                        |.|||.|:   .|..|..|.|:||.:         .|...|. |.|:......
Mouse   498 FGVKLMDFQAHRRGGTLNRKHIAPAFQPPLPPTDGNAL---------APAGPEP-PSQSSRADSS 552

  Fly   540 PAKPPLPN----LPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKS 600
            ....|:.:    |.|..||..|.|      |.|...|:.|.|..       |.::....|...::
Mouse   553 SGGGPVFSSTGILEQGLSPGDSSP------PKPKDSVSAAVPAA-------GRNSNQMTTVPNQA 604

  Fly   601 TDSIGSFKLKPDVP---------------QKPL-LPKRPTVLGVGVPKADGKSDDEGGTTPTQAT 649
            .....|.:|....|               :||. .|.:|..|..|.|  .|:|....||:|..:.
Mouse   605 QTGGNSHQLSVSTPHSAAGPSPHTLRRAVKKPAPAPPKPGNLPPGHP--GGQSSPGTGTSPKPSA 667

  Fly   650 IDNGNGSVRFKTEHFLDKLRQENGETNGTREVSST---TKENNHNHDPPATAADQNQQQAQPQVT 711
              ......:.:.:....:.:|:..:|.|.|..||:   .:..:|....|.|.....:|..:|..|
Mouse   668 --RSPSPPQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPSHPPPQPPTQPRLGEQGPEPGPT 730

  Fly   712 TPISPNSFQTP-----------------------------KRPTVPAPPPPTNWKSSD 740
            .|.:|....||                             .||:||.||.|....:.|
Mouse   731 PPQTPTPPSTPPLAKQNPSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPHPPGTHTVD 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	62/238 (26%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	78/208 (38%)
Arhgap17	NP_653112.2	BAR_Rich1	13..257	CDD:153302	63/252 (25%)
		RhoGAP_nadrin	246..446	CDD:239851	78/208 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..482		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..807		63/297 (21%)
		SH3-binding. /evidence=ECO:0000255	730..743		5/12 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847716
Domainoid	1	1.000	128	1.000	Domainoid score	I5291
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9984
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3256
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm43007
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	LDO	PTHR14130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3388
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.820