DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and Arhgap17

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_038945137.1	Gene:	Arhgap17 / 63994	RGDID:	628767	Length:	866	Species:	Rattus norvegicus

Alignment Length:	844	Identity:	228/844 - (27%)
Similarity:	382/844 - (45%)	Gaps:	148/844 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||::|..|.......::|.| ..|..|:
  Rat     1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.::|.||.....:||.:.|::.:|.:.: |.|:|..||:.|..:|..:.:.|:..|.:::..|
  Rat    61 -DAERRHKKLPLTALAQNMQEASAQLEESL-LGKMLETCGDAENQLAFELSQHEVFVEKEIMDPL 123

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK----RSHEAA-IRLEEPAAKVNHIKSQQEECELKLE 188
            ..|.:.||..|...::.::|.:.::.|::    ::|::: ...:...:|::.:|.:.:|...|:|
  Rat   124 YGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVE 188

  Fly   189 KERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARI---QDTIQGTEKSRFG 250
            :.:|..||.|...:|||.|........:..|.:||.:||..:..:|..:   ||  :..||..||
  Rat   189 QCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQD--KWAEKPAFG 251

  Fly   251 TSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDY 315
            |.|:|||..:.|||:..:|.|...|||.|::||||.|:|..::||:::|.||:..  .:.|...|
  Rat   252 TPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCS--TSHLDEFY 314

  Fly   316 QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLT 380
            .|||.:...||.|||||||||:|::||:::.::|....:.::...:.....|||.:|:.|.|||.
  Rat   315 SDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLI 379

  Fly   381 RFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELLISQ 443
            :||:.:.|.|.:|||:..|:|||:.||:||.:.:.:       :.::.::::.::  ::|.:|..
  Rat   380 KFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGT-------LAEIAAATSVHVVAVIEPIIQH 437

  Fly   444 WDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSE-------------VMESP------ 489
            .|:||.|||||.::    :.||. .:..||::.:...|||:             |||..
  Rat   438 ADWFFPGEVEFNVS----EAFVP-LATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKES 497

  Fly   490 ------------RYGTLRRQ---KANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEK 539
                        |.|||.|:   .|..|..|.|:||.:         .|...|| |.|:......
  Rat   498 FGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGNAL---------APAGPEL-PSQSSRADSN 552

  Fly   540 PAKPPLPN----LPQFQSPAASQPTQTQLEPLPPPPVTPAKPVP-MTRTQFFGLDNL-------- 591
            ....|:|:    |.|..||..|.|      |.|...|:.|.||. ....|...:.|.
  Rat   553 SVGGPVPSSSGILEQGLSPGDSSP------PKPKDSVSAAAPVAGRNSNQITTVPNQAQTGGNSH 611

  Fly   592 ------------PSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGVGV-PKADGKSDDEGGT 643
                        |||...|::.........||..| .|..|...:..|.|. ||...:|.    :
  Rat   612 QLSVGTAHSAAGPSPHTLRRAVKKPAPAPPKPGNP-PPGHPGGQSSPGTGTSPKPSTRSP----S 671

  Fly   644 TPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSST---TKENNHNHDPPATAADQNQQQ 705
            .|.|..........:.:.:....:.:|:..:|.|.|..||:   .:..||....|.|.....:|.
  Rat   672 PPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPNHPPPQPPTQPRLGEQG 736

  Fly   706 AQPQVTTPISPNSFQTP-----------------------------KRPTVPAPPPPTNWKSSD 740
            .:|..|.|.:|....||                             .||:||.||.|......|
  Rat   737 PEPGPTPPQTPTPPSTPPPAKQNSSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPNPPGTHMGD 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	62/238 (26%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	78/208 (38%)
Arhgap17	XP_038945137.1	BAR_Rich1	13..257	CDD:153302	63/252 (25%)
Arhgap17	XP_038945137.1	RhoGAP_nadrin	246..446	CDD:239851	78/208 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351287
Domainoid	1	1.000	128	1.000	Domainoid score	I5181
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9984
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3119
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm45071
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	LDO	PTHR14130
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.790