DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Fam13a

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_705802.1	Gene:	Fam13a / 58909	MGIID:	1889842	Length:	693	Species:	Mus musculus

Alignment Length:	694	Identity:	124/694 - (17%)
Similarity:	216/694 - (31%)	Gaps:	278/694 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 EIQEIST----LKRNVSRTLQEYT-SLKRSHEAAIRLEEPA-AKVNHIKSQQEECELKLEKERDA 193
            ::..:||    |:|.:...::|:. .:..:.:.:....||. :..:.|.::|...:.|  |:.|.
Mouse    29 QVSNVSTTGELLERTIRSAVEEHLFDVSNAGDQSSEDSEPGPSSASSIPTRQRGHQFK--KQDDV 91

  Fly   194 WAAQMLELIAKED------EIVSCIR-------------DYVLNQRNYHERALQHVNASLARIQD 239
            |.....|||.||:      ....||.             ||| .:|:..:|  |..::.||::.|
Mouse    92 WHGCDKELINKENIPSGFSGCAECILNSQEAERFQDDICDYV-GERSKPKR--QKSSSRLAKLSD 153

  Fly   240 TIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEA 304
            ...|.......:|::...|                     ||.|....:...|.::.|  ...:.
Mouse   154 NHDGALSMESLSSMQSQET---------------------LEPEAAEPLSSESKEIER--GGRDT 195

  Fly   305 QHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLP 369
            ||.:.|.                                  ::|.|..|.::.|
Mouse   196 QHCENPT----------------------------------MKIQEHPSLSDTK----------- 215

  Fly   370 KENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRID-------KSSNAPADYIGQV 427
                             |||:...:...::..    |:|  |::|       |:...|
Mouse   216 -----------------QQRNQDGEDQQESFV----PDM--PQLDLTALCDEKTWEEP------- 250

  Fly   428 NSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPR-- 490
                         |..|........|..|:.|..:|.          ::.|| .||:.|.|||
Mouse   251 -------------IPSWQPENADSDEARLSPQAGRLI----------HQFLD-EDSDPMLSPRFY 291

  Fly   491 -YGTLRRQKANA---PSPPTTNGNGIIMTTSQTSHRPHAKELFPQQ------------------- 532
             ||..|:...:.   ||||.::......::|..|:....::|.|.|
Mouse   292 AYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTPVQLTRRIQTLKKKIRKFEDRF 356

  Fly   533 ------TPEKQEKPAKPPL----PNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFG 587
                  .|...:|.|.|.:    .:|.:|:........:...|.|          .|.||.:
Mouse   357 EEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDL----------TPRTRQR--- 408

  Fly   588 LDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPK--RPTVLGVGVPKADGKSDDEGGTTPTQATI 650
            .:.||.         |.||...|.|..::.||.|  ||:|                     :||:
Mouse   409 SNTLPK---------SFGSQLEKEDEKKQELLDKAIRPSV---------------------EATL 443

  Fly   651 DNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKENNHN---------------HDPPATAAD 700
                       |..|.||:::..|::...::...||:...|               |..|.|..:
Mouse   444 -----------EGILRKLQEKRVESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKTE 497

  Fly   701 QNQQQAQPQVTTPISPNSFQTPKR-----PTVPAPPPPTNWKSS 739
            :       |:..|:. :.::..|:     .|||....|::.:.|
Mouse   498 R-------QIMKPLY-DRYRLVKQILSRASTVPIIGSPSSKRRS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	31/146 (21%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	25/213 (12%)
Fam13a	NP_705802.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..89		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..233		25/187 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..331		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..424		11/49 (22%)
		TMPIT	584..>670	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900