DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and arhgap22

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_690970.4	Gene:	arhgap22 / 562503	ZFINID:	ZDB-GENE-090313-87	Length:	698	Species:	Danio rerio

Alignment Length:	673	Identity:	163/673 - (24%)
Similarity:	266/673 - (39%)	Gaps:	174/673 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 RLKNILDKEIQEISTLKRNVSRTLQE------YTSLKRSHEAAIRLEEPAAKVNHIKSQQEECEL 185
            |.|:::..|:...|:  |..|.:|||      :...:||.....:|.....:.:|:...::|.|.
Zfish    16 RSKSMVMGELSRGSS--RPSSPSLQEQVVKAGWLKKQRSIMKNWQLRWFVLRTDHLYFYKDEEET 78

  Fly   186 KLEKERDAWAAQMLELIAKEDE--------IVSCIRDYVLNQRN--YHERALQHVNASLARIQDT 240
            |.:.......:|:.||.|..||        :..|..:   ..|:  .||..|...| |...::|.
Zfish    79 KPQGCIPLQGSQVNELTANPDEPGRHLFEIVPGCTGE---KDRSALSHEAFLLMAN-SQNDMEDW 139

  Fly   241 IQGTEK---SRFGTSL-KEHLTSTNREISY-----------IVELCCCCLLEHGLEEEGLLRVGC 290
            ::...:   :.||..: .:||..|   :.|           :||.|...:.|.||:||||.|:..
Zfish   140 VKAIRRVIWAPFGGGIFGQHLEDT---VQYERKFGPRLAPLLVEQCVDFIREQGLKEEGLFRMPG 201

  Fly   291 ASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAE---RH 352
            .:..::.::.|.:..  ..||.....|.|.:.|:|||||||||||::.:|.|:||:..|:   :.
Zfish   202 QANLVKELQDAFDCG--DKPLFDSNTDVHTVASLLKLYLRELPEPVIPFNKYEDFLTCAQLLLKD 264

  Fly   353 SEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSS 417
            .|......:|.:.| ||:.||..|:|:.:||..||..|..||||.||||.|..||:|.|:|:
Zfish   265 EEMGLGELVKQVST-LPQANYNLLKYICKFLDEVQSHSNENKMSVQNLATVFGPNILRPKIE--- 325

  Fly   418 NAPADYIGQVNSSSAANIIVELLISQWDYFFIG---EVEFYLT---LQKQKLFVEGKSKSNSSNE 476
                |.:..:..::....::.:|||:.:..::|   :|....|   .:.|:..||..|.....|.
Zfish   326 ----DPVSMMEGTTQVQQLMTVLISEHERLYVGNERDVSSDHTGSCPRGQRGMVEWISDEELLNC 386

  Fly   477 NLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQ------QTPE 535
            :.....|:|:||.. |:......|..:|.|.                   ::.||      .:|.
Zfish   387 SSPSQISKVVESVS-GSATSLDINMVAPTTA-------------------KMTPQGKVGLTVSPS 431

  Fly   536 KQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAK---------PVPMTRTQFF-GLDN 590
            ||.|       :||.::....|...:.|          |||         .:|.|..... ||.:
Zfish   432 KQVK-------SLPSWKYSFKSGGVRAQ----------PAKIGGSSVDVSTLPSTGNWLMNGLSS 479

  Fly   591 LPS----PTADRKSTDSIGSFKLK------------PDVPQKPLLPKRPTVLGVGVPKAD----- 634
            |.|    .:.:|...||..|.:|.            |.|...|.......:|..|...:|
Zfish   480 LRSHRRTSSGERMGKDSALSHRLSTYDNVTSSSLSVPSVASTPWSTSSCEILVGGSVGSDPSGLN 544

  Fly   635 --------GKSDDEGG--TTPTQA---------TIDNGN----GSVRFKTEHFLDKLRQENGETN 676
                    |:|:|...  |..::|         ..:|||    |:|            .|:.:|:
Zfish   545 SVKDWSVQGQSEDRSSEVTESSEALEMCVSSAGCSENGNVEDKGNV------------TEDNDTS 597

  Fly   677 GT------REVSSTTKENNHNHD 693
            .|      .|:....|:...|::
Zfish   598 TTALNSLVTELKGELKKQKANYE 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	32/149 (21%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	72/227 (32%)
arhgap22	XP_690970.4	PH-like	39..154	CDD:302622	24/118 (20%)
		PH	41..147	CDD:278594	21/109 (19%)
		RhoGAP_ARHGAP22_24_25	154..352	CDD:239855	69/210 (33%)
		BAR	<577..>683	CDD:299863	11/56 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910