DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and ARHGAP17

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_011544175.1	Gene:	ARHGAP17 / 55114	HGNCID:	18239	Length:	913	Species:	Homo sapiens

Alignment Length:	895	Identity:	231/895 - (25%)
Similarity:	385/895 - (43%)	Gaps:	210/895 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||::|..|.......::|.| ..|..|:
Human     1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.::|.||.....:||.:.|::.:| :|..|.|:|..||:.|..:|..:.:.|:..|.::|..|
Human    61 -DAERRHKKLPLTALAQNMQEASTQL-EDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPL 123

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK----RSHEAA-IRLEEPAAKVNHIKSQQEECELKLE 188
            ..|.:.||..|...::.::|.:.::.|::    ::|::: ...:...:|::.:|.:.:|...|:|
Human   124 YGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVE 188

  Fly   189 KERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGT--------- 244
            :.:|..||.|...:|||.|........:..|.:||.:||..:..:|..:: ..||:
Human   189 QCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMR-AHQGSPLNPLACVD 252

  Fly   245 -------------------------EKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEG 284
                                     ||..|||.|:|||..:.|||:..:|.|...|||.|::|||
Human   253 EVWCRCSVPLQLLGSLSWCHLDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEG 317

  Fly   285 LLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIA 349
            |.|:|..::||:::|.||:..  .:.|...|.|||.:...||.|||||||||:|:|||:::.::|
Human   318 LFRIGAGASKLKKLKAALDCS--TSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVA 380

  Fly   350 ERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRID 414
            ....:.::..::.....|||.:|:.|.|||.:||:.:.|.|.:|||:..|:|||:.||:||.|.:
Human   381 SVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNE 445

  Fly   415 KSSNAPADYIGQVNSSSAANI--IVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNEN 477
            .:       :.::.::::.::  ::|.:|...|:||..||||.::    :.||  ...:.|||.:
Human   446 GT-------LAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVS----EAFV--PLTTPSSNHS 497

  Fly   478 LDR-NDSE-------------VMESP------------------RYGTLRRQKAN----APSPPT 506
            ... |||:             |||..                  |.|||.|:..:    .|.|||
Human   498 FHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPT 562

  Fly   507 ---------------------TNGNGIIMTT---------------------------------S 517
                                 ::|.|.:.::                                 |
Human   563 DGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNS 627

  Fly   518 QT------------SHR-------------PHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAAS 557
            |.            ||:             ||......::......||..|| |..|..||.:.:
Human   628 QIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPP-PGHPGGQSSSGT 691

  Fly   558 QPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSP-TADRKSTDSIGSFKLKPDVPQKPLLPK 621
            ......|.| .||..:|:.|...| .|..|..:.||. :|.|:.:.|:...:.....|.:|  |.
Human   692 SQHPPSLSP-KPPTRSPSPPTQHT-GQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQP--PT 752

  Fly   622 RPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTK 686
            :.|      |....|.:.:|...|.....::|              |.|.:.....|....||..
Human   753 QAT------PLMHTKPNSQGPPNPMALPSEHG--------------LEQPSHTPPQTPTPPSTPP 797

  Fly   687 ENNHNHDPPA--TAADQNQQQAQPQVTTPISPNSFQTPK-RPTVPAPPPP 733
            ....|...||  |.|..|.:.|||...|...|.....|: ||:||.||.|
Human   798 LGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQP 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	64/269 (24%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	79/208 (38%)
ARHGAP17	XP_011544175.1	BAR_Rich1	13..289	CDD:153302	65/283 (23%)
ARHGAP17	XP_011544175.1	RhoGAP_nadrin	278..478	CDD:239851	79/208 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157320
Domainoid	1	1.000	133	1.000	Domainoid score	I5061
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9984
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3233
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm40935
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	LDO	PTHR14130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3388
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.820