DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and arhgap17a

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001017592.2	Gene:	arhgap17a / 550254	ZFINID:	ZDB-GENE-050417-56	Length:	847	Species:	Danio rerio

Alignment Length:	881	Identity:	221/881 - (25%)
Similarity:	371/881 - (42%)	Gaps:	238/881 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLP-ALSGGGGSGSGSS 63
            ||:||.::: :|.:.:.|:.|::....:|..|||:::..|.......:|:. .|.|..|:
Zfish     1 MKKQFNRMRQLANQTVGRAEKTEVLSDDLLQIERRMELVRVVSHNTHKKMAVCLQGQIGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.:||.||.....::||:.:...:|.::..:.|::..||:.|..:|..:::.|:..|.:::..|
Zfish    61 -DAEKRHKKLPLTALSQAMQDGGNQLGEESLIGKMMEMCGDAENRLASELMQHEMNIEKEILDPL 124

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK-------RSHEAAIRLEEPAAKVNHIKSQQEECELK 186
            ..:.:.:|..|...:|.:::.:.:|.|.:       :|..:....:...||.:.:|.:.:|...|
Zfish   125 NQLAEFDIPNILKQRRQLAKLVLDYDSARARWLQATKSIISGTNTQALTAKADSLKEEVDEAMNK 189

  Fly   187 LEKERDAWAAQMLELIAKEDEIVSCIRDYVL---NQRNYHERALQHVNASLARIQ-DTIQGTEKS 247
            :|..:|..:|.|....:||.:..   |.||:   .|.:||.::|..:.:.|..|| .....:||.
Zfish   190 MELCKDQLSADMYNFFSKEADYA---RYYVMLLEAQADYHRKSLTLLESVLPNIQAQQDSWSEKP 251

  Fly   248 RFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLP 312
            .|||:|.|||..::|||:..:|.|...|||.|::||||.|:...::||:::|.||:..  .:.|.
Zfish   252 AFGTALDEHLKRSSREIALPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCS--TSQLE 314

  Fly   313 LDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLR 377
            ..|.|||.:...||.|||||||||:||.||.::|:.:......:|...:.....:|||.|.||.|
Zfish   315 EFYSDPHAVAGALKSYLRELPEPLMTYQLYDEWIQASNVPDPDKRLQALWVTCDQLPKNNKANFR 379

  Fly   378 YLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELL 440
            ||.:||:.:.|.|.:|||:..|:|||:.||:||.:.:.|       :.::.::::.::  |::.:
Zfish   380 YLVKFLAKLAQESDVNKMTPSNIAIVLGPNLLWAKTEGS-------LAEMAAATSVHVVTIIDPI 437

  Fly   441 ISQWDYFFIGEVEFYL-------------------------TLQKQK----LFVEG--KSKSNSS 474
            |...|:||..:|:|.:                         |:::::    :..:|  ..:.:|:
Zfish   438 IQHADWFFPEDVDFNVSGMFSMPAPLPNNVNHLTPPDYDSGTIERKRPGSMVGPDGDMPRRDSSA 502

  Fly   475 NENLDRNDSEVMESPRYGTL--RRQKAN----APSPP--TTNGNGIIMTTSQTSHRP-------- 523
            |:.:|.|       ||.|..  |:|.|:    .|.||  ...|.|...|......:|
Zfish   503 NKLMDHN-------PRRGNTVPRKQHASPAFQPPLPPVEAAGGAGGQSTAELLLQQPAQVGLGLE 560

  Fly   524 --------------HAKELFPQQTPEKQEK--------PAK--------------------PPLP 546
                          .|::|..|.|.|...|        ||:                    .|.|
Zfish   561 NCQPGVALGMAALAAAQQLLAQHTEEISSKSRDSASTPPAQRNGTGGSGQLSVGTPVAGSTGPSP 625

  Fly   547 NLPQ--FQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKL 609
            ::.:  .:.||.:.|     :|..|||:.||              |.|.|...:..|..  ||..
Zfish   626 HMTRRGTKKPAPAPP-----KPANPPPIQPA--------------NQPVPQQTQSGTPQ--SFSP 669

  Fly   610 KPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGE 674
            .|    :||....||.|                 :|||.                       ..:
Zfish   670 SP----RPLSSYSPTNL-----------------SPTQT-----------------------QAQ 690

  Fly   675 TNGT--REVSSTTKENNHNHDPP------------ATAADQNQQQAQPQVTTPIS---------- 715
            ||.|  |..|:.......||.||            ....||.:..:.|...||.|
Zfish   691 TNTTPRRHSSNQPPIQAPNHPPPQPPTQTTPPPQTGMLGDQAEDPSPPHTPTPPSTPPPTAVFQD 755

  Fly   716 ------PNSFQT---------PK---RPTVPAPPPP 733
                  |..||:         ||   |||||.||.|
Zfish   756 SPSPTAPPVFQSGSLPRPRPVPKPRNRPTVPPPPQP 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	58/241 (24%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	80/208 (38%)
arhgap17a	NP_001017592.2	BAR	13..260	CDD:386243	59/255 (23%)
arhgap17a	NP_001017592.2	RhoGAP_nadrin	249..449	CDD:239851	80/208 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593092
Domainoid	1	1.000	127	1.000	Domainoid score	I5306
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3190
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	LDO	PTHR14130
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790