Protein Alignment RhoGAP92B and arhgap17

DIOPT Version :9

• Sequence 1: NP_001287417.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_002932512.1
• Gene: arhgap17 / 549590
• XenbaseID: XB-GENE-981776
• Length: 856
• Species: Xenopus tropicalis
• Alignment Length: 886
• Identity: 235/886 - (26%)
• Similarity: 377/886 - (42%)
• Gaps: 239/886 - (26%)

  Fly     1 MKRQFAKIKIAA-ENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRK-LPALSGGGGSGSGSS 63
            ||:||.::|:.| :.:.|:.|::....:|..|||::|..|.......:| |..|.|..|:
 Frog     1 MKKQFNRMKVLANQTVGRAEKTEVLSDDLLQIERRLDTVRLICHNAHKKLLGCLQGQPGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             |.:||.||.|...::|::.|....|..|..|.|.|.:|.:.|:.:|..:...|:..|..::..|
 Frog    61 -EAEKRYKKLSLMGVSQSMVEGCSLLGDDTLLAKTLYSCSDAEQQLAMELSMHEIAIEKDIMEPL 124

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK----RSHEAAIRLEEPAAKVNHIKSQQEECELKLEK 189
            ..:.:.||..|...::.:::.:.::.|.:    ::.::....:....|::.:|...:|...|:|:
 Frog   125 NQLAEVEIPNIQKQRKQLTKLVLDWDSARARFNQAQKSGANFQMQPGKMDSLKEDMDEAMNKVEQ 189

  Fly   190 ERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQ-DTIQGTEKSRFGTSL 253
            .||...|.|...::||.|........:..|..||.:||..:..:|..|| ...:.|||..|||.|
 Frog   190 CRDQLVADMYNFVSKEGEYGKYFVTLLETQAEYHRKALAALEKALPEIQAQQDKWTEKPAFGTPL 254

  Fly   254 KEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDP 318
            :|||..:.|||:..:|.|...|||.|::||||.|:...::||:::|.||:..  .:.|...|.||
 Frog   255 EEHLKRSGREIALPIEACVMMLLETGMKEEGLFRIAAGASKLKKLKAALDCS--TSQLEEFYSDP 317

  Fly   319 HVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSE--AERKTEIKA---ILTKLPKENYANLRY 378
            |.:...||.|||||||||:|:|||:::     .|:.  .::.|:::|   :..||||.|..|.||
 Frog   318 HAVAGALKSYLRELPEPLMTFNLYEEW-----NHAGNIPDQNTKLQALWVVCQKLPKPNLENFRY 377

  Fly   379 LTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELLI 441
            |.:||:.:...|.:|||:..|:|||:.||:||.|.:.:       :.::.::::.::  |:|.:|
 Frog   378 LVKFLAKLSHHSDINKMTPSNIAIVLGPNLLWARHEGT-------LAEIAAATSVHVMTIIEPII 435

  Fly   442 SQWDYFFIGEVEFYLT----------------------------LQKQKLF---VEGKSKSNSSN 475
            ...|:||..|::|.::                            |:|::.|   ::|:.|.:||.
 Frog   436 QHADWFFPDELDFNVSGAFVPVAPTTHSNNVPYTGNDMSYEFGPLEKKRPFSMVMDGELKRDSSG 500

  Fly   476 ENLDRNDSEVME----SPRYGTLRRQKANAPS-----PPTTNGNGI--------IMTTSQTSHRP 523
                   .:||:    :.|.|||.| |..||:     |||.:||..        :..|..||.:|
 Frog   501 -------LKVMDYYLNTRRGGTLNR-KHGAPTVQPPLPPTESGNQSDHSASSLDVGPTVATSVQP 557

  Fly   524 HA------------------KELFPQQTPEK--------------------------------QE 538
            .|                  |:|.|..||..                                .:
 Frog   558 TASADPVLTHSNDETSTFKTKDLTPATTPPSLRNGTHQPPGGGNAVVPAQGNANPSPISSRRGTK 622

  Fly   539 KPA----KPPLP--------------NLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQF 585
            |||    ||.:|              |:|...||   :|:.|...|.||..:|.....|.|.|..
 Frog   623 KPAPAPPKPVVPHSGQLANSGSSISANVPPSISP---KPSNTAHNPSPPSSITSQGVAPATSTHS 684

  Fly   586 FGLDNLPSPTADRKSTDSIGSFKLKP--DVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQA 648
            .|       |..|:.:.|      :|  ..|..|  |.:|                     |||:
 Frog   685 HG-------TLPRRHSGS------QPFIQAPSHP--PPQP---------------------PTQS 713

  Fly   649 ---TIDNGNGS-VRFKTEHFLDKLRQENGETNGTREVSSTTKENNHNHDP--------------- 694
               ::...|.. |.|.||                   |||.:.::..|.|
 Frog   714 ATLSLSKANAQPVAFPTE-------------------SSTDQSSSPPHTPTPPDTPPLGVEHPGS 759

  Fly   695 -PATAADQNQQQAQPQVTTPISPNSFQTPK-RPTVPAPPPP 733
             ||.......|.:.||..|...|.....|: |||||.||.|
 Frog   760 QPAAPEATQTQPSPPQTGTLPRPRPVPKPRVRPTVPPPPQP 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	62/235 (26%)
		RhoGAP_nadrin	245..452	CDD:239851	81/213 (38%)
arhgap17	XP_002932512.1	BAR	13..257	CDD:386243	63/249 (25%)
		RhoGAP_nadrin	246..445	CDD:239851	81/212 (38%)
		DUF5585	515..>849	CDD:375359	78/345 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9984
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3127
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm48131
Panther	1	1.100	-	-	LDO	PTHR14130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3388
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.090