DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and FAM13B

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001372923.1	Gene:	FAM13B / 51306	HGNCID:	1335	Length:	937	Species:	Homo sapiens

Alignment Length:	510	Identity:	103/510 - (20%)
Similarity:	188/510 - (36%)	Gaps:	151/510 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ALQHVNASLARIQDTIQGTEKSRFGTSLKE-----HLTSTNREISYIVELCCCCLLEH-GLEEEG 284
            :|.:.|:.||          ...||..|.|     |   .:.|:.:||......:.|| |||::|
Human     8 SLSNCNSVLA----------NKIFGIPLDELQQGGH---PDNEVPFIVRHVVDYIEEHGGLEQQG 59

  Fly   285 LLRV-GCASTK--LR-RMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDF 345
            |.:| |.|.|.  || |.....|...||     :...|..| |:|:.:|:|||||::..:|:...
Human    60 LFQVNGNAETVEWLRQRYDSGEEVDLVK-----EADVPSAI-SLLRFFLQELPEPVIPGSLHIHL 118

  Fly   346 IRIAERH-SEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
            :::::.: :|.|...:::.:|.:||..||:.|::|.|||:.|..... ...|:.:||.|..|::.
Human   119 MQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFGPDVF 182

  Fly   410 WPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSS 474
            ....|.......:.:        :.|:..||.:.:::|                  |.:.:..||
Human   183 HIYTDVEDMKEQEIV--------SRIMAGLLENYYEFF------------------ENEEEDFSS 221

  Fly   475 NENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEK 539
            |:                         .|..|...|.:.....:.....|.:|| |::..||..
Human   222 ND-------------------------LSSITEQVNELSEEEEEDEKLEHIEEL-PEEGAEKSN- 259

  Fly   540 PAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSI 604
                .:|.:.|.:.      |:..||         :..|..|.|....:..||:.|
Human   260 ----DMPEVVQLRM------TENILE---------SNSVTATSTHISPISILPAST--------- 296

  Fly   605 GSFKLKPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLR 669
                   |:.::.:                            :|.::.....::...:|.|..|:
Human   297 -------DILERTI----------------------------RAAVEQHLFDLQSSIDHDLKNLQ 326

  Fly   670 QENGETNGTREVSSTTKENNHNH----DPPATAADQNQQQAQPQVTTPISPNSFQ 720
            |::...|...|......|.::|.    |....|::.|:..::|..:|.:...:.|
Human   327 QQSVVCNNEAESIHCDGEGSNNQIDIADDIINASESNRDCSKPVASTNLDNEAMQ 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	8/35 (23%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	59/217 (27%)
FAM13B	NP_001372923.1	RhoGAP_FAM13A1a	19..205	CDD:239858	56/203 (28%)
FAM13B	NP_001372923.1	RecQL4_SLD2_NTD	879..918	CDD:421279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900