DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and Arhgap25

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001102717.1	Gene:	Arhgap25 / 500246	RGDID:	1562105	Length:	648	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	128/550 - (23%)
Similarity:	216/550 - (39%)	Gaps:	130/550 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 NILDKEIQEISTLKRN---VSRTLQEYTSLKRSHEAAIRLEE----------PAAKVNHIKSQQE 181
            |.|::.| ::..||:.   |....|.|..||.......:.||          |.:.|..|.:..|
  Rat    42 NPLERPI-KMGWLKKQRSIVKNWQQRYFVLKARQLYYYKDEEDSKPQGCMYLPGSTVKEIATNPE 105

  Fly   182 ECELKLEKERDAWAAQMLELI-AKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTE 245
            |.           ...:.|:| |..|:..:....|||...:..|  ::.....|.|:..|..|
  Rat   106 EA-----------GKFVFEVIPASSDQNRTGQDSYVLMASSQVE--MEEWVKFLRRVAGTPSG-- 155

  Fly   246 KSRFGTSLKE----------HLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKH 300
             :.||..|.|          ||      :..:||.|...:||||:.|||:.|:......:::::.
  Rat   156 -AVFGQRLDETVAYEQKFGPHL------VPILVEKCSEFILEHGVSEEGIFRLPGQDNLVKQLRD 213

  Fly   301 ALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAE--RHSEAERKTEIKA 363
            |.:|.. :.....| .|.|.:.|:||||||:||||::.::.|:.|:...:  ...||:.:.|::.
  Rat   214 AFDAGE-RPSFDRD-TDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELEK 276

  Fly   364 ILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRID-------------- 414
            .|:.||::||..|.|:.|||..:|...|:||||..|||.|:..|::..:::
  Rat   277 QLSILPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQR 341

  Fly   415 --------------KSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFV 465
                          ||.:||.....|.|.:..|.:....:  .||           ..:...|
  Rat   342 VMTMMIRDHEVLFPKSKDAPLSPPAQKNDAKKAPVPRSSV--GWD-----------ATEDPPL-- 391

  Fly   466 EGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAK---- 526
               |:::|.|......|:.....|:.|. :.|:.:..:|....|:..:.:..:|...|:.|
  Rat   392 ---SRTDSFNNTASSPDATSPTGPQPGD-QHQEDSGKAPKENPGDWKMQSRKRTQTLPNRKCFLT 452

  Fly   527 -----------ELFPQQ--TPEKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPV 578
                       |:|..:  :|..:.|..:.....:.|.....::....:..:.:|.|||:...|.
  Rat   453 SAFQGTTSSKLEIFKNEFWSPSSEAKAGEGHRRTMSQDLRHLSNDQRTSTYDNVPNPPVSQGNPA 517

  Fly   579 PMTRTQFFGLDNLPSPTADRK-----STDS 603
                      ..|..|.:|.|     ||||
  Rat   518 ----------GELSPPASDSKRDAPVSTDS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	33/150 (22%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	68/246 (28%)
Arhgap25	NP_001102717.1	PH_RhoGap25-like	45..157	CDD:270083	27/128 (21%)
		PH	47..149	CDD:278594	24/115 (21%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	59/205 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810