DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and INPP5B

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001352749.1	Gene:	INPP5B / 3633	HGNCID:	6077	Length:	913	Species:	Homo sapiens

Alignment Length:	348	Identity:	68/348 - (19%)
Similarity:	128/348 - (36%)	Gaps:	76/348 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 IIESEL--ETEAKVVRRLKNILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNH 175
            ::..||  :|..::||.|..:.:..|..:|..||.......:|..|| .....|...:.......
Human   562 VVNDELYRKTLEEIVRSLDKMENANIPSVSLSKREFCFQNVKYMQLK-VESFTIHNGQVPCHFEF 625

  Fly   176 IKSQQEECELK-----------------LEKERDAWAAQM--LELIAKEDEIVSCI-------RD 214
            |....||...|                 :|.:.:.:..:|  .:|.:.||:|...:       :|
Human   626 INKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKD 690

  Fly   215 YVLN-QRNYHERALQHVNASLARIQDTI-----------------QGTEKSRFGTSLKEHLTSTN 261
            |.|: ..||..........:|..:::.|                 .|.:.|:..:.::     ..
Human   691 YFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPME-----IP 750

  Fly   262 REISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQD-----PHVI 321
            :|:..:|:.    |..:.:::|.|.:    ...||.     |.:|::..|.....|     .|.:
Human   751 KELWMMVDY----LYRNAVQQEDLFQ----QPGLRS-----EFEHIRDCLDTGMIDNLSASNHSV 802

  Fly   322 GSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIV 386
            ...|.|:|..||||::.|:.|.:.:..:..:      |..|.:::.||..:.....||..||..:
Human   803 AEALLLFLESLPEPVICYSTYHNCLECSGNY------TASKQVISTLPIFHKNVFHYLMAFLREL 861

  Fly   387 QQRSALNKMSSQNLAIVMSPNML 409
            .:.||.|.:....||.:....:|
Human   862 LKNSAKNHLDENILASIFGSLLL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	33/189 (17%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	36/170 (21%)
INPP5B	NP_001352749.1	INPP5B_PH	6..150	CDD:318889
		INPP5c_INPP5B	265..558	CDD:197327
		RhoGAP_OCRL1	692..912	CDD:239845	42/217 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900