DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and Inpp5b

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001094225.1	Gene:	Inpp5b / 362590	RGDID:	1311511	Length:	916	Species:	Rattus norvegicus

Alignment Length:	431	Identity:	100/431 - (23%)
Similarity:	158/431 - (36%)	Gaps:	111/431 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ENLSRSS--------KSDSK--DSELEAIERQVDR--YRDTIEKIVRKLPALSGGGGSGSGSSEE 65
            :|:|:.|        .||.|  .|..|...|.|:.  ||.|:|:|||.|
  Rat   534 KNISQLSYQSHMSLKTSDHKPVSSVFEIGVRVVNEELYRKTLEEIVRSL---------------- 582

  Fly    66 QDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKN 130
             ||....|.. .:..:..|...|..|.|.||           |....|...::..|.:.:    |
  Rat   583 -DKMENANIP-SVTLSKREFCFENVKYMQLQ-----------TATFTIHNGQVPCEFEFI----N 630

  Fly   131 ILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLE-----EPAAKVNHIKSQQEE-CELKLEK 189
            ..|:|......|....||..    .|..|| ..|.||     ..|.|:|..|...|: ..|.|.:
  Rat   631 KPDEETYCKQWLTAKPSRGF----LLPDSH-VEIELELFVNKATATKLNSGKDTIEDILVLHLHR 690

  Fly   190 ERDAWAAQMLELIAKEDEIVSC----------IRDYVLNQRNYHERALQHVN-ASLARIQDTIQG 243
            .:|.:      |....:.:.||          :|:.:|      :..|:.|| .:|..:|
  Rat   691 GKDYF------LSVTGNYLPSCFGSPIHTLCYMREPIL------DLPLKIVNELTLMTVQ----- 738

  Fly   244 TEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVK 308
            |...|   |..|......:|:..:|:.    |..:.:::|.|.:    ...||.     |.:|::
  Rat   739 TADDR---SQLEKPMEIPKELWMMVDY----LYRNAVQQEDLFQ----QPGLRP-----EFEHIR 787

  Fly   309 TPLP---LDY--QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKL 368
            ..|.   :|:  .:.|.:...|.|:|..||||::.|:.|...:..:..|      |..|.:::.|
  Rat   788 DCLDTGMIDHLCANNHSVAEALLLFLESLPEPVICYSAYHSCLECSGSH------TASKQVISTL 846

  Fly   369 PKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
            |..:.....||..||..:.:.||.|.:....||.:....:|
  Rat   847 PTFHKNVFSYLMAFLQELLKNSAKNHLDENILASIFGSLLL 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	57/248 (23%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	39/170 (23%)
Inpp5b	NP_001094225.1	INPP5B_PH	6..150	CDD:293381
		INPP5c_INPP5B	268..561	CDD:197327	7/26 (27%)
		RhoGAP_OCRL1	695..915	CDD:239845	50/232 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900