DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Arhgap8

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001004242.1	Gene:	Arhgap8 / 300115	RGDID:	1303143	Length:	425	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	76/260 - (29%)
Similarity:	118/260 - (45%)	Gaps:	41/260 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 RFGTSLKEHLTSTNRE--ISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTP 310
            :||.|| ::|...|:.  |..::......|.|.||..|||.|...::..:|:::...:.   ..|
  Rat   192 QFGVSL-QYLRDKNQGELIPPVLRWTVTYLREKGLHTEGLFRRSASAQTVRQVQRLYDQ---GKP 252

  Fly   311 LPL-DYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYA 374
            :.. ||.|.|:...|||.:|||||:||||:..|:..:.|....|.. |.|..:.||..||:.|||
  Rat   253 VNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQILGITSVESSL-RVTHCRLILRSLPEHNYA 316

  Fly   375 NLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVEL 439
            .||||..||..|...|..|||:|.|||.|...|::|         |:..:..:::....|:..||
  Rat   317 VLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIW---------PSQGVASLSALVPLNLFTEL 372

  Fly   440 LISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSP 504
            ||..:|..|                        |:.|....:..:.:|:.:.|.:.::.....:|
  Rat   373 LIEYYDKVF------------------------SAQEGPGEHIRDTVETKQAGPVTKEFTQTGTP 413

Fly 505 504
Rat 414 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	4/8 (50%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	71/206 (34%)
Arhgap8	NP_001004242.1	SEC14	12..157	CDD:238099
Arhgap8	NP_001004242.1	RhoGAP	191..381	CDD:413382	70/202 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1511935at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920