DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP92B and Sh3bp1

DIOPT Version :9

Sequence 1:NP_001287417.1 Gene:RhoGAP92B / 42371 FlyBaseID:FBgn0038747 Length:740 Species:Drosophila melanogaster
Sequence 2:NP_001165452.1 Gene:Sh3bp1 / 300067 RGDID:1306275 Length:689 Species:Rattus norvegicus


Alignment Length:735 Identity:194/735 - (26%)
Similarity:322/735 - (43%) Gaps:159/735 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKRQFAKIKIAAENLSRSSKSDSKD---SELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSG 61
            ||||..:::..|...|.....::.:   .:|..:|::::..:.....:.::|.| |.|..|:   
  Rat     2 MKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGA--- 63

  Fly    62 SSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVR 126
               :.|||.||.....::.|:.||.|||..|..:.|.|.....::..:|..:.|.|:..|..|::
  Rat    64 ---DMDKRVKKLPLMALSTAMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQ 125

  Fly   127 RLKNILDKEIQEISTLKRNVSRTLQEYTSLK----------------------RSHEAAIRLEEP 169
            .|..:.::|:..|...|:::.:.:.::.:||                      .:|.|.      
  Rat   126 PLNRLSEEELPAILKRKKSLQKLVSDWNTLKSRLSQAAKNSGSSQSLGGGSSSHTHMAT------ 184

  Fly   170 AAKVNHIKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASL 234
            |.||..:|..:||.:.|:|:.:|.:.|.:.....|||...:.....:..|.:||.::|..::.:|
  Rat   185 ANKVETLKEDEEELKRKVEQCKDEYLADLYHFSTKEDSYANYFTHLLEIQADYHRKSLTSLDTAL 249

  Fly   235 ARIQDTIQGTEKSR----------FGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVG 289
            |.::|.....:.|.          :|.||:.||....|:|:..:|.|...||..|::||||.|:.
  Rat   250 AELRDNHSQADSSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLA 314

  Fly   290 CASTKLRRMKHALEAQHVKTPLPLD--YQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERH 352
            ..::.|:|:|..:.:.    |..|:  ..|||.:...||.|||||||||:|.:||.|::|.|...
  Rat   315 AGASVLKRLKQTMASD----PHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLK 375

  Fly   353 SEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSS 417
            ....|...:..:.::||:||:.|||||.:||:::.:...:|||:..|:|||:.||:|||...:..
  Rat   376 EPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGD 440

  Fly   418 NAPADYIGQVNSSSAANI----IVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENL 478
            .|      |::::|.::|    :||:||...|..|.|::.|.::.....|..:.|..|...:|.|
  Rat   441 QA------QLDAASVSSIQVVGVVEVLIQNADTLFPGDINFSVSGIFSGLAPQEKPNSQQVSEEL 499

  Fly   479 ----------------------------DRNDSE--------VMESPRYGT------LRRQKANA 501
                                        :|.:||        |..||...|      .|:.|..|
  Rat   500 APVAVPATAATPTPTPAPTPAPASMTVKERTESELPKPASPKVSRSPTDTTALAEDMTRKTKRPA 564

  Fly   502 PSPPTTNGNGIIMTTSQTS---HRPHAKEL--------FPQQTPEK------QEKPAKPPLPNLP 549
            |:.||       |...|.|   ..|.|..|        .||..|.:      :.....||||   
  Rat   565 PARPT-------MPPPQPSSSRSSPPALSLPAGSVSPGTPQALPRRLVGTSLRAPTVPPPLP--- 619

  Fly   550 QFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLP------SPTADRKSTDSIGSFK 608
                ||..||.:.|...||..| .||.||         :.|:|      :.|.||...:::|.. 
  Rat   620 ----PAPPQPARRQSRRLPVSP-CPASPV---------ISNMPAQVDQGAATEDRGGPEAVGGH- 669

  Fly   609 LKPDVPQKPLLPKRPTVLGV 628
                 |..|:||.:|...|:
  Rat   670 -----PPTPVLPPQPRPRGL 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP92BNP_001287417.1 BAR 27..257 CDD:299863 58/262 (22%)
RhoGAP_nadrin 245..452 CDD:239851 78/222 (35%)
Sh3bp1NP_001165452.1 Interaction with CGNL1. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 1..275 61/284 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 6/21 (29%)
BAR_SH3BP1 16..275 CDD:153304 56/270 (21%)
RhoGAP 272..473 CDD:295372 77/210 (37%)
Interaction with CD2AP. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 470..689 57/245 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..689 50/208 (24%)
SH3-binding. /evidence=ECO:0000250|UniProtKB:P55194 611..620 4/15 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351286
Domainoid 1 1.000 128 1.000 Domainoid score I5181
eggNOG 1 0.900 - - E1_KOG4270
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 253 1.000 Inparanoid score I3119
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000886
OrthoInspector 1 1.000 - - otm45071
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14130
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X445
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.850

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