Protein Alignment RhoGAP92B and Prune2

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001406496.1
• Gene: Prune2 / 293823
• RGDID: 1311350
• Length: 3080
• Species: Rattus norvegicus
• Alignment Length: 812
• Identity: 151/812 - (18%)
• Similarity: 273/812 - (33%)
• Gaps: 226/812 - (27%)

  Fly    14 NLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEEQDKRTKKNS---H 75
            :||.:|...|::|| ||:|.:.:.|  |::.:         .|.:.:.:|:.|.|.|.:.|   :
  Rat  1377 SLSVTSSPQSEESE-EALEVEKEPY--TLDSL---------AGQTETPTSDSQTKDTHEESLMDN 1429

  Fly    76 YKIAQA---LDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKNI------ 131
            ..:.:|   ||..  .|.|:|||.::     |||:|.|..|:..|.|....:....:|.
  Rat  1430 RNLEEANTTLDRI--NLIKNMPLSEM-----ELEETEACNILRPERENGKLIYESSQNFGVWDGP 1487

  Fly   132 ---------LDKEIQEISTLKRNVSRTLQ--------------EYTSLKRS----HEAAIRLEE- 168
                     :..||....|.:|...|:|:              |.|....|    :::::.|..
  Rat  1488 TDSDVWDSHISYEIAMNPTCQRTEERSLEALSPGNYDKDSLSSECTRSSASSPDLNDSSVALSSW 1552

  Fly   169 ---PAAKVNHIKSQQEECELKLEKERDAWAAQM-LELIAKEDEIVSCIRDYVLNQRNYHERALQH 229
               |:|  :|....|::...::.:|.:.:..:. :.:|.:..:.....:|...|..:..:.....
  Rat  1553 TYGPSA--DHQNENQDDRNKQIHQEPELFTTEAHVGVITEMKDFAKPRKDEFGNMSDQEDPQFPA 1615

  Fly   230 VNASLARIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTK 294
            ::      .|...|      |:|.......|::...|          .|..:|..|:..|....:
  Rat  1616 IS------NDPFNG------GSSSSSSSLGTDKYSEY----------SHAYQEGNLMTRGQEENE 1658

  Fly   295 LRRMKHA-LEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERK 358
            |..::.| .|...:   :.......|..|...:|..:||           ....:|:|.||
  Rat  1659 LNSLEIAEPEGSRI---ISTSSGSGHDSGGEEELLEKEL-----------HLATVAQRESE---- 1705

  Fly   359 TEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKM--SSQNLAIVMSPNMLWPRIDKSSNAPA 421
                 :...||.         ..||...|.:..|:..  ||:.   :.:.|...|..|...::|
  Rat  1706 -----VCNSLPD---------PEFLVTEQSKPELSVFVGSSEP---IENENKSSPFYDSQQSSP- 1752

  Fly   422 DYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQK-----------LFVEGKSKSNSSN 475
                                .||....:.:.:...|.::::           ...:|.:.::..|
  Rat  1753 --------------------GQWILSPLVQADIQDTSKEEEARGADTGTVMDTMWQGSASTDRKN 1797

  Fly   476 ENLDRNDSEVMESPRYGT---------LRRQKANA--PSPPTTNGNGIIMTTSQTSHRPHAKELF 529
                 .|.:.:|...:.|         .|..||.|  .:...:|..|.:.|||     |..:...
  Rat  1798 -----GDPDTLEMLGFSTDSSEWWNPAARDGKATASVSAEELSNSEGELETTS-----PIFQNAG 1852

  Fly   530 PQQTP-EKQEKPAKPPLPNLP---QFQSP---AASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFG 587
            |...| :...||......| |   :.:||   :....:|.:|..:.|      |.:.....||..
  Rat  1853 PWSVPVQDDSKPVDTGSTN-PFSGELKSPFLDSDGDKSQEKLWNIQP------KQLDSDANQFSQ 1910

  Fly   588 LDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPK--RPTVL------GVGVPKADGKSDDEGGTT 644
            |..| ....|:.|...........|:|.:.|..:  :.::|      |..:...|.......|.:
  Rat  1911 LVIL-DQIKDKDSGQQTAMSSTAGDLPSETLAQEQCQESMLSVWDHAGPALTHRDENGCVSAGIS 1974

  Fly   645 PTQATIDNGNGSVRFKTEHF---------LDKLRQENGETNGTREVSS-----TTKENNHNHDPP 695
            ||:...:||....:....|.         |||:   |..|...|:..|     :..|:.||..|.
  Rat  1975 PTECQQENGWEPEKSYLSHVTHSRTPTENLDKI---NAPTQLIRKPDSDWDSPSPSEHQHNFVPD 2036

  Fly   696 ATAA--DQNQQQAQPQVTTPISPNSFQTPKRP 725
            ....  ::..|.|.      .||:.:...|:|
  Rat  2037 ILHGNFEEGGQLAS------ASPDLWMDVKQP 2062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	51/273 (19%)
		RhoGAP_nadrin	245..452	CDD:239851	34/209 (16%)
		PRK13855	495..>650	CDD:172376	37/171 (22%)
Prune2	NP_001406496.1	DHHA2	214..>277	CDD:460719
		BNIP2	2778..2895	CDD:463609
		CRAL_TRIO_2	2897..3034	CDD:463965