DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Fam13b

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_017456403.1	Gene:	Fam13b / 291694	RGDID:	1310484	Length:	871	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	81/314 - (25%)
Similarity:	137/314 - (43%)	Gaps:	63/314 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ALQHVNASLARIQDTIQGTEKSRFGTSLKE-----HLTSTNREISYIVELCCCCLLEH-GLEEEG 284
            :|.:.|:.||          ...||..|.|     |   .:.|:.:||......:.|| |||::|
  Rat     8 SLSNCNSDLA----------SKIFGIPLDELQQGGH---PDNEVPFIVRHVVDYIEEHGGLEQQG 59

  Fly   285 LLRV-GCASTK--LR-RMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDF 345
            |.:| |.|.|.  || |.....|...||     :...|..| |:|:.:|:|||||::..:|:...
  Rat    60 LFQVNGNAETVEWLRQRYDSGEEVDLVK-----EADVPSAI-SLLRFFLQELPEPVIPGSLHIHL 118

  Fly   346 IRIAERH-SEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
            :::::.: :|.|...:::.:|.:||..||:.|::|.|||:.|..... ...|:.:||.|..|::.
  Rat   119 LQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFGPDVF 182

  Fly   410 WPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEF------YLTLQKQKLFVEGK 468
            ....|.......:.:        :.|:..||.:.:::|...|.:|      .:|.|..:|
  Rat   183 HIYTDVEDMKEQEIV--------SRIMAGLLENYYEFFENEEEDFSSNDLSSITEQVNEL----- 234

  Fly   469 SKSNSSNENLDRNDSEVMESPRYGTLRRQKANAP-------SPPTTNGNGIIMT 515
            |:....:|.||    .|.|.|..|.  .:.|..|       :..|...:.:|.|
  Rat   235 SEEEEEDEKLD----HVEELPEEGV--EKSAGVPEVLQSRMAENTQESDSVIAT 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	8/35 (23%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	59/217 (27%)
Fam13b	XP_017456403.1	RhoGAP_FAM13A1a	19..205	CDD:239858	56/203 (28%)
		RecQL4_SLD2_NTD	535..>615	CDD:421279
		RecQL4_SLD2_NTD	813..852	CDD:421279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900