DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and SPBC19C2.10

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_595695.1	Gene:	SPBC19C2.10 / 2540758	PomBaseID:	SPBC19C2.10	Length:	501	Species:	Schizosaccharomyces pombe

Alignment Length:	511	Identity:	85/511 - (16%)
Similarity:	184/511 - (36%)	Gaps:	108/511 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKI-KIAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSE 64
            |.:.|||: :...|......:..:...:..:::.:.|.:...::||.|.............|..:
pombe     1 MNKHFAKLSQWTGEKFGFDRQKTTLSDDFCSLKGETDAWLVGMDKIHRSCTRWVRNMDKRKGLLD 65

  Fly    65 EQDKRTK----KNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVV 125
            |:||:..    .:|..::.|||..|:......:...|.:...|.|::...:.:..|.|
pombe    66 EKDKQLPVTHVGSSFVELGQALSHSSSNSHTYIMYGKSMVEIGHLQEEFMDYLNNSFL------- 123

  Fly   126 RRLKNILDKEIQEISTLKRNVSRTLQEYTSL----KRSHEAAIRLEEPAAKVNHIKSQQEECE-- 184
                              .|:..:|.|:.:|    |:.....:..:..:.|:...|.::.:.|
pombe   124 ------------------ANLENSLAEFKALDVKEKKMENRRLVFDALSTKIQKAKKEESKLEED 170

  Fly   185 -----LKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNA----SLARIQDT 240
                 .|.|:..:.:..:|::|...|.:.|..:...:..|..:|:::|..:..    ..::.:|.
pombe   171 LRNARAKYEESLEEFEDRMVQLKELEPDRVENVVRLLQMQIRFHQKSLDLLKGLEMNGFSKKRDN 235

  Fly   241 IQGTEKSRFGTSLKEHLTSTN---REISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHAL 302
            :...:::....|:..:::|||   ...:.|.|:            :..|:...:|.:.....:.|
pombe   236 VNIPKRTYSARSIPSNISSTNVATTPSNTIFEM------------DDTLKADSSSNEYHSPTNTL 288

  Fly   303 EAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAE----------------- 350
            .:.|.:.    |..:..:..|....:..:      .||  || :..|:
pombe   289 PSYHTEA----DLDNSSIASSNRTQHTED------NYN--KD-VSDAQNSLGQSAVDLTTPSSPP 340

  Fly   351 --RHSEAE----RKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
              ||::.:    :.|.:|.  ..|..|....|.:....||  ...:.|::.......:..||:.:
pombe   341 IPRHTKPKLSTTQSTPVKP--ASLQSEEDIQLSFKQPELS--ASSAELDEKLKSQCNVSPSPSNI 401

  Fly   410 WPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFV 465
                   |:||...:.:..||..|:|....:: :..|.|..|.|..|.|:|..|.:
pombe   402 -------SDAPPSKLNRSYSSPLASISSRKVV-RMKYSFEPETENELKLKKGDLLL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	37/248 (15%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	38/232 (16%)
SPBC19C2.10	NP_595695.1	BAR_MUG137_fungi	21..235	CDD:153277	35/238 (15%)
		CENP-T_N	<245..384	CDD:292789	26/167 (16%)
		SH3	430..482	CDD:302595	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000