DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Arhgap22

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006519017.1	Gene:	Arhgap22 / 239027	MGIID:	2443418	Length:	738	Species:	Mus musculus

Alignment Length:	538	Identity:	128/538 - (23%)
Similarity:	207/538 - (38%)	Gaps:	155/538 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 EKERDAWAAQMLELIAKE----DEIVSCIRDYVL------NQRNYHERALQHVNASL--ARIQDT 240
            |:|:.....:.|.|:|..    ::.|..||..:.      ..|:.|...::.::|.:  .|::||
Mouse   138 EREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGTSRSSHVHPVKPLSAGIFGQRLEDT 202

  Fly   241 IQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQ 305
            :.  .:.:||..|          ...:||.|...:.|.||.||||.|:...:..:|.::.:.:..
Mouse   203 VH--HERKFGPRL----------APLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCG 255

  Fly   306 HVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAE--RHSEAERKTEIKAILTKL 368
              :.||.....|.|.:.|:|||||||||||::.:..|:||:..|:  ...|.|...|:...::.|
Mouse   256 --EKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNL 318

  Fly   369 PKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAA 433
            |:.||..|||:.:||..||..|.:||||.||||.|..||:|.|:|:       |.:..:..:|..
Mouse   319 PQANYNLLRYICKFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIE-------DPVTIMEGTSLV 376

  Fly   434 NIIVELLISQWDYFFI-----------GEVEFYLTLQKQKLFVEGKSKSNS------SNENLDRN 481
            ..::.:||.:....|.           |.||:    ..:::..:.:.:..|      ...:||..
Mouse   377 QHLMTVLIRKHGQLFAATSLEEPASPHGTVEW----GSEEVTRDHRGEPGSPGLPTHRTSSLDGP 437

  Fly   482 DSEVM---ESPRYG----------------------TLRRQKANAPSPPTTN-----------GN 510
            .:.|:   ..||.|                      :.|:|.:.:.||...|           ||
Mouse   438 AAAVLSRTSPPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGN 502

  Fly   511 GIIM-TTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPA------------------- 555
            .:|. .:|..|||..:.....:.|...|.......:|...||.|.|
Mouse   503 WLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSWSVASSSREASVS 567

  Fly   556 -------------ASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTD----- 602
                         :|..|:..|||.|                      |||.:...:|.|
Mouse   568 SCTACRASNSSACSSLHTEWALEPSP----------------------LPSSSEGHQSPDLGHSL 610

  Fly   603 ---SIGSFKLKPDVPQKP 617
               .:||...:|:.|..|
Mouse   611 DEPCVGSGSSEPNDPGSP 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	17/80 (21%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	70/219 (32%)
Arhgap22	XP_006519017.1	PH-like	62..177	CDD:388408	8/38 (21%)
		RhoGAP_ARHGAP22_24_25	193..391	CDD:239855	71/218 (33%)
		Macoilin	<529..>719	CDD:370635	22/122 (18%)
		HCR	<638..719	CDD:284517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810