Protein Alignment RhoGAP92B and ARHGAP8

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001017526.1
• Gene: ARHGAP8 / 23779
• HGNCID: 677
• Length: 464
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 94/384 - (24%)
• Similarity: 142/384 - (36%)
• Gaps: 121/384 - (31%)

  Fly   221 NYHERALQH-------VNASLARIQDTIQGTEKSR------------------FGTSLKEHLTST 260
            ||.....:|       :...:.|..:.:|...:.|                  ||.|| ::|...
Human   171 NYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSL-QYLKDK 234

  Fly   261 NRE--ISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPL-DYQDPHVIG 322
            |:.  |..::......|.|.||..|||.|   .|..::.::......:...|:.. ||.|.|:..
Human   235 NQGELIPPVLRFTVTYLREKGLRTEGLFR---RSASVQTVREIQRLYNQGKPVNFDDYGDIHIPA 296

  Fly   323 SILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQ 387
            .|||.:|||||:||||:..|:..:.|....|.. |.|..:.||..||:.||..||||..||..|.
Human   297 VILKTFLRELPQPLLTFQAYEQILGITCVESSL-RVTGCRQILRSLPEHNYVVLRYLMGFLHAVS 360

  Fly   388 QRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEV 452
            :.|..|||:|.|||.|...|::|         |:..:..:::....|:..||||
Human   361 RESIFNKMNSSNLACVFGLNLIW---------PSQGVSSLSALVPLNMFTELLI----------- 405

  Fly   453 EFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTS 517
            |:|     :|:|                                   :.|..|..:|
Human   406 EYY-----EKIF-----------------------------------STPEAPGEHG-------- 422

  Fly   518 QTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAK 576
                          ..|.:|...|.|....:|:.|:...::||      |||.|:..|:
Human   423 --------------LAPWEQGSRAAPLQEAVPRTQATGLTKPT------LPPSPLMAAR 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	10/60 (17%)
		RhoGAP_nadrin	245..452	CDD:239851	69/227 (30%)
		PRK13855	495..>650	CDD:172376	16/82 (20%)
ARHGAP8	NP_001017526.1	CRAL_TRIO_2	32..196	CDD:463965	4/24 (17%)
		RhoGAP	222..412	CDD:470621	71/219 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..464		9/29 (31%)