Protein Alignment RhoGAP92B and Arhgap25

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001032816.1
• Gene: Arhgap25 / 232201
• MGIID: 2443687
• Length: 648
• Species: Mus musculus
• Alignment Length: 641
• Identity: 146/641 - (22%)
• Similarity: 243/641 - (37%)
• Gaps: 160/641 - (24%)

  Fly   118 LETEAKVVRRLKNILDKEIQ----------------EISTLKRN---VSRTLQEYTSLKRSHEAA 163
            |:.||..:.|.::::..|..                ::..||:.   |....|.|..|:......
Mouse    13 LKAEASKIARSRSVMTGEQMAAFHPPTTPNPLERPIKVGWLKKQRSIVKNWQQRYFVLRAQQLYY 77

  Fly   164 IRLEE----------PAAKVNHIKSQQEECELKLEKERDAWAAQMLELI-AKEDEIVSCIRDYVL 217
            .:.||          |.:.|..|.:..||.           ...:.|:| |..|:.......|||
Mouse    78 YKDEEDSKPQGCMYLPGSTVKEIATNPEEA-----------GKFVFEVIPASSDQNRIGQDSYVL 131

  Fly   218 NQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKE----------HLTSTNREISYIVELCC 272
            ...:..|  ::.....|.|:..|..|   :.||..|.|          ||      :..:||.|.
Mouse   132 MASSQVE--MEEWVKFLRRVAGTPSG---AVFGQRLDETVAYEQKFGPHL------VPILVEKCA 185

  Fly   273 CCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLL 337
            ..:||||:.|||:.|:......:::::.|.:|.. :.....| .|.|.:.|:||||||:||||::
Mouse   186 EFILEHGVSEEGIFRLPGQDNLVKQLRDAFDAGE-RPSFDRD-TDVHTVASLLKLYLRDLPEPVV 248

  Fly   338 TYNLYKDFIRIAE--RHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNL 400
            .::.|:.|:...:  ...||:.:.|:...|:.||::||..|.|:.|||..:|...|:||||..||
Mouse   249 PWSQYEGFLLCGQLMNADEAKAQQELVKQLSTLPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNL 313

  Fly   401 AIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFV 465
            |.|:..|::..:::.    ||..   :..:.....::.::|...:..|
Mouse   314 ATVIGVNLIRSKVED----PAVI---MRGTPQIQRVMTMMIRDHEVLF----------------- 354

  Fly   466 EGKSKSNSSNENLDRNDSEVMESPRYGT---------LRRQKA---NAPSPPTTNGNGIIMTTSQ 518
             .|||....:....:||::....||...         |.|..:   .|.||..|:..|.:.:...
Mouse   355 -PKSKDAPISPPAQKNDAKKAPVPRSSVGWDATEDPPLSRTDSFSNTASSPDATSPTGPLPSDQH 418

  Fly   519 TSHRPHAKELFPQQTP---EKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPM 580
            ......|    |::.|   :.|.:.....|||...|.:.|....|.::||              :
Mouse   419 QEDSGKA----PRENPGDWKMQSRKRTQTLPNRKCFLTSAFQGTTSSKLE--------------I 465

  Fly   581 TRTQFFGLDNLPSPTADRKS------TDSIGSFKLKPD--------VPQKPLLPKRPTVLGVGVP 631
            .:.:|:      ||:::.|:      |.|.....|..|        ||..|.....|.. .:..|
Mouse   466 FKNEFW------SPSSEAKAGEGHRRTMSQDLRHLSNDQRTSTYDNVPTSPQSQGNPAG-ALSPP 523

  Fly   632 KADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKE 687
            .:|.|.|   ....|.:.::.|:   :...|..||.|:         |.|.|..||
Mouse   524 ASDSKRD---ALVSTDSEMEAGS---KNSGEDDLDSLQ---------RTVQSLQKE 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	34/178 (19%)
		RhoGAP_nadrin	245..452	CDD:239851	63/218 (29%)
		PRK13855	495..>650	CDD:172376	35/174 (20%)
Arhgap25	NP_001032816.1	PH_RhoGap25-like	45..157	CDD:270083	25/127 (20%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	62/212 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..559		49/242 (20%)
		SMC_N	<545..>643	CDD:481474	9/29 (31%)