DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Arhgap24

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_036020963.1	Gene:	Arhgap24 / 231532	MGIID:	1922647	Length:	804	Species:	Mus musculus

Alignment Length:	537	Identity:	126/537 - (23%)
Similarity:	231/537 - (43%)	Gaps:	115/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 RIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKH 300
            :::||::  .:.|:|          ||....:||.|...:.:.||:||||.|:...:..::.::.
Mouse   191 KLEDTVR--YEKRYG----------NRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQD 243

  Fly   301 ALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIA---ERHSEAERKTEIK 362
            |.:..  :.|......|.|.:.|:|||||||||||::.|..|:||:..|   .:..||..|..:|
Mouse   244 AFDCG--EKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELMK 306

  Fly   363 AILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQV 427
            .: ..||..||..|:|:.|||..||..|.:||||:||||.|..||:|.|:::       |.:..:
Mouse   307 QV-KSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVE-------DPLTIM 363

  Fly   428 NSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSN---------ENLDRNDS 483
            ..:.....::.::||:.|..|..:.|      .|....:|.:.:|:..         :|.:.|::
Mouse   364 EGTVVVQQLMSVMISKHDRLFPKDTE------PQSKPQDGPNSNNNDGHKKATMGQLQNKENNNT 422

  Fly   484 EVMESPRYGTLRRQKANAPSPP----TTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPP 544
            :  |||    :||...:.|..|    ..||:...::.|:|:.        |:.:..|.:....||
Mouse   423 K--ESP----VRRCSWDKPESPQRSSVDNGSPTALSGSKTNS--------PRNSIHKLDISRSPP 473

  Fly   545 L--PNLPQFQSPAA----SQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDS 603
            |  ...|.|...:.    ...:.:..|.:..|..||...:...||     .:|.| :..:..|.|
Mouse   474 LMVKKNPAFNKGSGIVTNGSFSSSNAEGVEKPQTTPNGSLQARRT-----SSLKS-SGTKMGTHS 532

  Fly   604 IGSFKLKPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKL 668
            :.:..::                 :|:...|...:...|.  :.:.:.||..::|.      :|.
Mouse   533 VQNGTVR-----------------MGILNTDTLGNSLNGR--SMSWLPNGYVTLRD------NKQ 572

  Fly   669 RQENGET----------NGTREVSSTTKENNHNHDPPATAADQNQQQAQPQVTTPISPNSFQTPK 723
            ::..||:          |..::.||.:.::.|:.| .||.:..:.:.:.|:.:.....::...|:
Mouse   573 KEPAGESGQHNRLSTYDNVHQQFSSMSLDDKHSVD-SATWSTSSCEISLPENSNSCRSSTTTCPE 636

  Fly   724 R---------PTVPAPP 731
            :         |.:..||
Mouse   637 QDFYVGNFEDPVLDGPP 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	4/20 (20%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	69/209 (33%)
Arhgap24	XP_036020963.1	PH-like	20..186	CDD:418428
		RhoGAP_ARHGAP22_24_25	186..384	CDD:239855	70/214 (33%)
		Smc	<705..>791	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810