DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Fam13b

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006525911.1	Gene:	Fam13b / 225358	MGIID:	2447834	Length:	905	Species:	Mus musculus

Alignment Length:	411	Identity:	97/411 - (23%)
Similarity:	165/411 - (40%)	Gaps:	85/411 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 ALQHVNASLARIQDTIQGTEKSRFGTSLKE-----HLTSTNREISYIVELCCCCLLEH-GLEEEG 284
            :|.:.|:.||          ...||..|.|     |   .:.|:.:||......:.|| |||::|
Mouse     8 SLSNCNSDLA----------SKIFGIPLDELQQGGH---PDNEVPFIVRHVVDYIEEHGGLEQQG 59

  Fly   285 LLRV-GCASTK--LR-RMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDF 345
            |.:| |.|.|.  || |.....|...||     :...|..| |:|:.:|:|||||::..:|:...
Mouse    60 LFQVNGNAETVEWLRQRYDSGEEVDLVK-----EADVPSAI-SLLRFFLQELPEPVIPGSLHIHL 118

  Fly   346 IRIAERH-SEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
            :::::.: :|.|...:::.:|.:||..||:.|::|.|||:.|..... ...|:.:||.|..|::.
Mouse   119 LQLSQDYNNEDEFGRKLRFLLQQLPPVNYSLLKFLCRFLANVASHHE-EIWSANSLAAVFGPDVF 182

  Fly   410 WPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSS 474
            ....|.......:.:.::.:.         |:..:..||..|.|.:.:.....:..:..|....|
Mouse   183 HIYTDVEDMKEQEIVSRIMAG---------LLENYYEFFENEEEDFSSNDLSSITEQAGSSIPHS 238

  Fly   475 NENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEK 539
            .|:.::...|.:|........|:..|..|.          ...:.....|.:|| |:   |..||
Mouse   239 LESGEQAFHEALEKGITAVKERRDVNELSE----------EEEEDEKLEHIEEL-PE---EGVEK 289

  Fly   540 PAKPP-------LPNLPQFQSPAASQPTQTQLEPLPPPP-------VTPAKPVPMTRT------Q 584
            .|..|       ..||....|..||    |:::......       :..:|||..|..      |
Mouse   290 SAGMPEVLQLRMTENLLDSDSVTAS----TRIDAAAATTTNASDGNIKCSKPVAGTTADNEVMQQ 350

  Fly   585 FFGLDNLPSPTADRKSTDSIG 605
            .|..:       |:|:.:|:|
Mouse   351 DFVFE-------DQKNNESVG 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	8/35 (23%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	58/217 (27%)
Fam13b	XP_006525911.1	RhoGAP_FAM13A1a	19..205	CDD:239858	55/204 (27%)
Fam13b	XP_006525911.1	Drc1-Sld2	566..>645	CDD:371692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900