DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Arhgap44

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006532934.1	Gene:	Arhgap44 / 216831	MGIID:	2144423	Length:	814	Species:	Mus musculus

Alignment Length:	830	Identity:	233/830 - (28%)
Similarity:	356/830 - (42%)	Gaps:	185/830 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::: :|.:.:.|:.|::....:|..:|::::..:.......:||.| |.|..|:
Mouse     1 MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             |.|||:||.....:||.|.|.:..|..|..|.|:|..|||.|..:|:.:|..||:.|..|:..|
Mouse    61 -EADKRSKKLPLTTLAQCLVEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPL 124

  Fly   129 KNILDKEIQEISTLKRNV---------SRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECE 184
            ..:.:.||..|...::::         |||..:.||  :|...:..|:...||.:.::.:.||..
Mouse   125 FLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTS--KSSGLSSSLQPAGAKADALREEMEEAA 187

  Fly   185 LKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQG-TEKSR 248
            .::|..||..:|.|...:|||.:..:..:..:..|..||.::|..:.|.|.:|:...:. .||..
Mouse   188 NRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPS 252

  Fly   249 FGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPL 313
            ||..|:|||..:.|||::.:|.|...|||.|::||||.||..:::||:::|.||:...|...
Mouse   253 FGKPLEEHLMISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQ--- 314

  Fly   314 DYQ-DPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLR 377
            :|. |||.|...||.|||||||||:|:.||.::|:.:....:.:|...:.....||||.|:.|::
Mouse   315 EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIK 379

  Fly   378 YLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELL 440
            ||.:|||.:.:...:|||:..|:|||:.||:|||:.:.:       |.::.::.:..|  |:|.:
Mouse   380 YLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQSEGN-------ITEMMTTVSLQIVGIIEPI 437

  Fly   441 ISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTL-RRQKANAPSP 504
            |...|:||.||:||.||          .|..:..:.|.:.|.|. |.||..... |||...|..|
Mouse   438 IQHADWFFPGEIEFNLT----------GSYGSPVHVNHNANYSS-MPSPDMDPADRRQPEQARRP 491

  Fly   505 ---PTTN---------------GNGI-IMTTSQTSHRPHAKELFPQQTPEKQEKPAKP-----PL 545
               .|.|               ..|: :|.||..:.|..:........|...:.||.|     ||
Mouse   492 LSVATDNMMLEFYKKDGLRKIQSMGVRVMDTSWVARRGSSAGRKASCAPPSMQPPAPPSELAAPL 556

  Fly   546 PN-LPQF--QSPA----ASQPTQTQLEPLP---------------------------PPPVTPAK 576
            |: ||:.  .|||    |..|:...|:|.|                           |.|.|...
Mouse   557 PSPLPEQVPDSPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTPCPGTQLG 621

  Fly   577 PVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVP-------------------QKPLLPKR 622
            |.|.........|.  ||...||.:..:.  .:.|.||                   ..|..|..
Mouse   622 PQPAASPSQLPADQ--SPHTLRKVSKKVA--PIPPKVPFVQPGTVSDQPVGQPSPVSLSPTPPST 682

  Fly   623 PTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKE 687
            |:..|:..|  .|.|...|..:|..|
Mouse   683 PSPYGLSYP--PGYSMASGQLSPASA--------------------------------------- 706

  Fly   688 NNHNHDPPATAADQNQQQAQPQVTTPISPNSFQTPK---RPTVPAPPPPT 734
                  ||.         |.|.|.|.....|..|||   |||:|.|.||:
Mouse   707 ------PPL---------ASPSVFTSTLAKSRPTPKPRQRPTLPPPQPPS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	69/240 (29%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	82/209 (39%)
Arhgap44	XP_006532934.1	BAR_Rich2	13..260	CDD:153303	70/254 (28%)
		RhoGAP	249..449	CDD:383032	82/209 (39%)
		PHA03247	<529..809	CDD:223021	57/273 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847717
Domainoid	1	1.000	128	1.000	Domainoid score	I5291
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3256
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm43007
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	O	PTHR14130
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3388
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780