Protein Alignment RhoGAP92B and Sh3bp1

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001303613.1
• Gene: Sh3bp1 / 20401
• MGIID: 104603
• Length: 680
• Species: Mus musculus
• Alignment Length: 699
• Identity: 188/699 - (26%)
• Similarity: 318/699 - (45%)
• Gaps: 96/699 - (13%)

  Fly     1 MKRQFAKIKIAAENLSRSSKSDSKD---SELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSG 61
            ||||..:::..|...|.....::.:   .:|..:|::::..:.....:.::|.| |.|..|:
Mouse     2 MKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGA--- 63

  Fly    62 SSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVR 126
               :.|||.||.....::..:.||.|||..|..:.|.|.....::..:|..:.|.|:..|..|::
Mouse    64 ---DMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQ 125

  Fly   127 RLKNILDKEIQEISTLKRNVSRTLQEYTSLK-RSHEAAIRL---------------EEPAAKVNH 175
            .|..:.::|:..|...|:::.:.:.::.:|| |..:||...               ...|.||..
Mouse   126 PLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEM 190

  Fly   176 IKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDT 240
            :|.::||.:.|:|:.:|.:.|.:.....|||...:.....:..|.:||.::|..::.:||.::|.
Mouse   191 LKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDN 255

  Fly   241 IQGTEKSR----------FGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKL 295
            ....:.|.          :|.||:.||....|:|:..:|.|...||..|::||||.|:...::.|
Mouse   256 HSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVL 320

  Fly   296 RRMKHALEAQHVKTPLPLD--YQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERK 358
            :|:|..:.:.    |..|:  ..|||.:...||.|||||||||:|.:||.|::|.|.......|.
Mouse   321 KRLKQTMASD----PHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARL 381

  Fly   359 TEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADY 423
            ..:..:.::||:||:.|||||.:||:::.:...:|||:..|:|||:.||:|||...:...|
Mouse   382 EALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQA---- 442

  Fly   424 IGQVNSSSAANI----IVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENL------ 478
              |::::|.::|    :||.||...|..|.|::.|.::.....|..:.|..|...:|.|
Mouse   443 --QLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVP 505

  Fly   479 -DRNDSEVMESPRYGTLR-RQKANAPSP--------PTTNGNGIIMTTSQTSHRPHAKELFPQQT 533
             .........:|....:| |.:|:.|.|        ||.........|.:|.....|:...|  .
Mouse   506 APATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMP--P 568

  Fly   534 PEKQEKPAKPPLPNLPQFQ-SPAASQPTQTQL------EPLPPPPVTPAKPVPMTRTQFFGL--- 588
            |:.....:.||.|:||... ||...|....:|      .|..|||:.|..|.| .|.|...|
Mouse   569 PQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQP-ARRQSRRLPAS 632

  Fly   589 ---DNLPS------PTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGV 628
               .|:|:      .|.||...:::|..      |..|.||.:|...|:
Mouse   633 PVISNMPAQVDQGVATEDRGGPEAVGGH------PPPPALPPQPRPRGL 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	58/256 (23%)
		RhoGAP_nadrin	245..452	CDD:239851	78/222 (35%)
		PRK13855	495..>650	CDD:172376	43/162 (27%)
Sh3bp1	NP_001303613.1	Interaction with CGNL1. /evidence=ECO:0000250|UniProtKB:Q9Y3L3	1..275		61/278 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		6/21 (29%)
		BAR_SH3BP1	16..275	CDD:153304	56/264 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..184		2/23 (9%)
		RhoGAP	272..473	CDD:470621	77/210 (37%)
		Interaction with CD2AP. /evidence=ECO:0000250|UniProtKB:Q9Y3L3	470..680		51/215 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..680		48/197 (24%)
		SH3-binding. /evidence=ECO:0000269|PubMed:8438166	607..616		4/8 (50%)