DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP92B and Sh3bp1

DIOPT Version :9

Sequence 1:NP_001287417.1 Gene:RhoGAP92B / 42371 FlyBaseID:FBgn0038747 Length:740 Species:Drosophila melanogaster
Sequence 2:NP_001303613.1 Gene:Sh3bp1 / 20401 MGIID:104603 Length:680 Species:Mus musculus


Alignment Length:699 Identity:188/699 - (26%)
Similarity:318/699 - (45%) Gaps:96/699 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKRQFAKIKIAAENLSRSSKSDSKD---SELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSG 61
            ||||..:::..|...|.....::.:   .:|..:|::::..:.....:.::|.| |.|..|:   
Mouse     2 MKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGA--- 63

  Fly    62 SSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVR 126
               :.|||.||.....::..:.||.|||..|..:.|.|.....::..:|..:.|.|:..|..|::
Mouse    64 ---DMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQ 125

  Fly   127 RLKNILDKEIQEISTLKRNVSRTLQEYTSLK-RSHEAAIRL---------------EEPAAKVNH 175
            .|..:.::|:..|...|:::.:.:.::.:|| |..:||...               ...|.||..
Mouse   126 PLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEM 190

  Fly   176 IKSQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDT 240
            :|.::||.:.|:|:.:|.:.|.:.....|||...:.....:..|.:||.::|..::.:||.::|.
Mouse   191 LKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDN 255

  Fly   241 IQGTEKSR----------FGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKL 295
            ....:.|.          :|.||:.||....|:|:..:|.|...||..|::||||.|:...::.|
Mouse   256 HSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVL 320

  Fly   296 RRMKHALEAQHVKTPLPLD--YQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERK 358
            :|:|..:.:.    |..|:  ..|||.:...||.|||||||||:|.:||.|::|.|.......|.
Mouse   321 KRLKQTMASD----PHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARL 381

  Fly   359 TEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADY 423
            ..:..:.::||:||:.|||||.:||:::.:...:|||:..|:|||:.||:|||...:...|    
Mouse   382 EALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQA---- 442

  Fly   424 IGQVNSSSAANI----IVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENL------ 478
              |::::|.::|    :||.||...|..|.|::.|.::.....|..:.|..|...:|.|      
Mouse   443 --QLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVP 505

  Fly   479 -DRNDSEVMESPRYGTLR-RQKANAPSP--------PTTNGNGIIMTTSQTSHRPHAKELFPQQT 533
             .........:|....:| |.:|:.|.|        ||.........|.:|.....|:...|  .
Mouse   506 APATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMP--P 568

  Fly   534 PEKQEKPAKPPLPNLPQFQ-SPAASQPTQTQL------EPLPPPPVTPAKPVPMTRTQFFGL--- 588
            |:.....:.||.|:||... ||...|....:|      .|..|||:.|..|.| .|.|...|   
Mouse   569 PQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQP-ARRQSRRLPAS 632

  Fly   589 ---DNLPS------PTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGV 628
               .|:|:      .|.||...:::|..      |..|.||.:|...|:
Mouse   633 PVISNMPAQVDQGVATEDRGGPEAVGGH------PPPPALPPQPRPRGL 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP92BNP_001287417.1 BAR 27..257 CDD:299863 58/256 (23%)
RhoGAP_nadrin 245..452 CDD:239851 78/222 (35%)
Sh3bp1NP_001303613.1 Interaction with CGNL1. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 1..275 61/278 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 6/21 (29%)
BAR_SH3BP1 16..275 CDD:153304 56/264 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..184 2/23 (9%)
RhoGAP 272..473 CDD:295372 77/210 (37%)
Interaction with CD2AP. /evidence=ECO:0000250|UniProtKB:Q9Y3L3 470..680 51/215 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..680 48/197 (24%)
SH3-binding. /evidence=ECO:0000269|PubMed:8438166 607..616 4/8 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847714
Domainoid 1 1.000 128 1.000 Domainoid score I5291
eggNOG 1 0.900 - - E1_KOG4270
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 246 1.000 Inparanoid score I3256
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000886
OrthoInspector 1 1.000 - - otm43007
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14130
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X445
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.850

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