DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and Inpp5b

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_006502867.1	Gene:	Inpp5b / 16330	MGIID:	103257	Length:	994	Species:	Mus musculus

Alignment Length:	388	Identity:	83/388 - (21%)
Similarity:	142/388 - (36%)	Gaps:	87/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 YRDTIEKIVRKLPALSGGGGSGSGSSEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANC 102
            ||.|:|:|||.|                 ||....|     ..::..|.:|.            |
Mouse   649 YRKTLEEIVRSL-----------------DKMENAN-----IPSVTLSKREF------------C 679

  Fly   103 GELEKTMAECIIESELETEAKVVRRLK-----NILDKEIQEISTLKRNVSRTLQEYTSLKRSHEA 162
            .|..|.|       :|:||:..:...:     ..::|..:| |..|:.::....:...|..|| .
Mouse   680 FENVKYM-------QLQTESFTIHNSQVPCQFEFINKPDEE-SYCKQWLTARPSKGFLLPDSH-V 735

  Fly   163 AIRLE-----EPAAKVNHIKSQQEE-CELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVLNQRN 221
            .|.||     ..|.|:|..|...|: ..|.||:.:|.:      |....:.:.||....:.....
Mouse   736 EIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYF------LSVSGNYLPSCFGSPIHTLCY 794

  Fly   222 YHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLL 286
            ..|..|   :..|..:.|....:.::....|..|:.....:|:..:|:.    |..:.:::|.|.
Mouse   795 MREPIL---DLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDY----LYRNAVQQEDLF 852

  Fly   287 RVGCASTKLRRMKHALEAQHVKTPLPLDYQDP-----HVIGSILKLYLRELPEPLLTYNLYKDFI 346
            :    ...||.     |..|::..|.....|.     |.:...|.|:|..||||::.|:.|...:
Mouse   853 Q----QPGLRP-----EFDHIRDCLDTGMIDQLCANNHSVAEALLLFLESLPEPVICYSAYHSCL 908

  Fly   347 RIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNML 409
            ..:..::.:      |.|:..||..:.....||..||..:.:.||.|.:....||.:....:|
Mouse   909 ECSGNYAAS------KQIILTLPSFHKNVFNYLMAFLQELLKNSANNHLDENILASIFGSLLL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	48/229 (21%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	37/170 (22%)
Inpp5b	XP_006502867.1	INPP5B_PH	1..150	CDD:374793
		INPP5c_INPP5B	346..639	CDD:197327
		RhoGAP_OCRL1	773..991	CDD:239845	44/221 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810