Protein Alignment RhoGAP92B and PRUNE2

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_006717045.1
• Gene: PRUNE2 / 158471
• HGNCID: 25209
• Length: 3104
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 123/590 - (20%)
• Similarity: 201/590 - (34%)
• Gaps: 158/590 - (26%)

  Fly   278 HGLEEEGLLRVG-CASTKLRRMKHALEAQHVKTPLPLDYQDPHV------IGSILKLYLRELPEP 335
            |.|.:||.|.:. ..|:.|......||:..||...|::..|.:|      ...:||..|:|.||
Human    95 HQLNDEGKLSITLVGSSVLASEDKTLESAVVKVINPVEQSDANVEFRESSSSLVLKEILQEAPE- 158

  Fly   336 LLTYN---------LYKDFIRIAERHSEAERKTEIKAILTKL-----PKENYANLRYLTRF---- 382
            |:|..         |:|.....:|:.|  |::.||.:||.:.     |:|:..|:...|:|
Human   159 LITEQLAHRLRGSILFKWMTMESEKIS--EKQEEILSILEEKFPNLPPREDIINVLQETQFSAQG 221

  Fly   383 LSIVQ-QRSALNKMSSQNLAIVMS------PNMLWPRIDKSSNAPAD------------------ 422
            |||.| ....|.::|...:.:.:|      .|.|:     .||..:|
Human   222 LSIEQTMLKDLKELSDGEIKVAISTVSMNLENCLF-----HSNITSDLKAFTDKFGFDVLILFSS 281

  Fly   423 YIGQ------------VNSSSAANIIVELLISQ-----WDYFFIG--EVEFY------LTLQKQK 462
            |:.:            .|....:.|..||...|     .:.|..|  |:..|      :|..:..
Human   282 YLSEEQQPRRQIAVYSENMELCSQICCELEECQNPCLELEPFDCGCDEILVYQQEDPSVTCDQVV 346

  Fly   463 LFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKE 527
            |.|:         |.::|...|::.:.|..:   .:|.|.|.|.:.|:..||....:...|....
Human   347 LVVK---------EVINRRCPEMVSNSRTSS---TEAVAGSAPLSQGSSGIMELYGSDIEPQPSS 399

  Fly   528 L-FPQQTPEKQEK---------PAKPPLPNLPQFQSPAASQPTQTQLEPLPP------------P 570
            : |.:..|:..:.         ....|...|...:|..:|:.:...|....|            |
Human   400 VNFIENPPDLNDSNQAQVDANVDLVSPDSGLATIRSSRSSKESSVFLSDDSPVGEGAGPHHTLLP 464

  Fly   571 PVTPAKPVPM-----------TRTQFFGLDNL-PSPTADRKSTDSIGSFKLKPD---VPQKPL-- 618
            .:....|:|.           ...:.|.|.|. |:|.|..:|..|..|....|.   .|...|
Human   465 GLDSYSPIPEGAVAEEHAWSGEHGEHFDLFNFDPAPMASGQSQQSSHSADYSPADDFFPNSDLSE 529

  Fly   619 --LPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGETNGTREV 681
              ||..|..|       ||...:....:.:......|..|:....|.|:.  ||::...|..|.:
Human   530 GQLPAGPEGL-------DGMGTNMSNYSSSSLLSGAGKDSLVEHDEEFVQ--RQDSPRDNSERNL 585

  Fly   682 SSTTKENNHNHDP----------PATAADQNQQQAQPQVTTPISPNSFQTPKRPTVPA--PPPPT 734
            |.|....:.:..|          |.|..: :..::.|....|.|..:....::.|...  .||.|
Human   586 SLTDFVGDESPSPERLKNTGKRIPPTPMN-SLVESSPSTEEPASLYTEDMTQKATDTGHMGPPQT 649

  Fly   735 NWKSS 739
            :.:.|
Human   650 HARCS 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257
		RhoGAP_nadrin	245..452	CDD:239851	56/242 (23%)
		PRK13855	495..>650	CDD:172376	37/195 (19%)
PRUNE2	XP_006717045.1	DHHA2	221..>278	CDD:460719	12/61 (20%)
		BNIP2	2799..2909	CDD:463609
		CRAL_TRIO_2	2921..3058	CDD:463965