Protein Alignment RhoGAP92B and sh3bp1

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_031756949.1
• Gene: sh3bp1 / 101733422
• XenbaseID: XB-GENE-984798
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 671
• Identity: 165/671 - (24%)
• Similarity: 296/671 - (44%)
• Gaps: 99/671 - (14%)

  Fly     1 MKRQFAKIK-IAAENLSRSSK-SDSKDSELEAIERQVDRYRDTIEKIVRKL-PALSGGGGSGSGS 62
            ::||..::: :|.....||.. :|....:|...::||:..:.....:.::| ..|....||
 Frog     2 IQRQLHRMRQLANHGPGRSQDVTDILTEDLLLADQQVEPVKKLAHLVGKRLVSCLQAPAGS---- 62

  Fly    63 SEEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRR 127
              :::|:.||.:...::..:.|..||:..:..:::.:.....:|..:::.:.:.|:..|..|::.
 Frog    63 --DREKKLKKLALSSLSWTMAECLKEIDSESRMRRTVEMGCCVEGILSQDLADFEISLERDVLQP 125

  Fly   128 LKNILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEE---------------PAAKVNHIK 177
            |..:.::::..|...::.:.:.:.::.:.|.      ||.:               .|||:..:|
 Frog   126 LAKLSEEDLPTILKHRKQLQKLITDWNTAKS------RLSQIQKNINAGQGGGSTGTAAKLESLK 184

  Fly   178 SQQEECELKLEKERDAWAAQMLELIAKEDEIVSCIRDYVL---NQRNYHERALQHVNASLAR--- 236
            .:::|...|||:.:|.:.|.:.....||.|   |.|.::.   .|..||:::|.|:..:|..
 Frog   185 EEEDELRRKLEQSKDEYIADLYNYTTKEKE---CERYFIQLLELQAEYHKKSLSHLTDALEELKD 246

  Fly   237 -----IQDTIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLR 296
                 :||:|:......:|..|:.||.....||:..:..|...||..|::||||.|:...::.|:
 Frog   247 LQKETVQDSIEQASAEVYGVPLETHLAKFECEIAVPISACVRMLLAQGMQEEGLFRLAAGASVLK 311

  Fly   297 RMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEI 361
            ::|..|.|.  .:.|.....:||.:...||.|||||||||:||.|:.|::..|......:|....
 Frog   312 KLKACLRAG--ASDLSNFMSEPHAVAGALKSYLRELPEPLMTYELFDDWMTCASTKDPEKRLECY 374

  Fly   362 KAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPR-------IDKSSNA 419
            :....|||..||.|||||.:|::.:.:...:|||:..|:|||:.||:||.:       :|.:|.:
 Frog   375 RDACKKLPAANYNNLRYLIKFMAKLAEHQEVNKMTPSNIAIVLGPNLLWAKSDGETSLLDMASAS 439

  Fly   420 PADYIGQVNS--SSAANIIVELLISQWDYFFIGEVEFY------LTLQKQKLFVEGKSKSNSS-- 474
            |...:..|..  :.||||..|      |..| |..|.|      |..|...:..:...|:..:
 Frog   440 PIIVVSVVEGLLNCAANIFPE------DVDF-GVSEAYHETSSVLPAQCSGIKNQEWPKAEETAL 497

  Fly   475 -NENLDRNDSEVMES-PRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQ 537
             ..|:..|...|.|| ..:..|.:...:...||.           :.|:....|......|..|.
 Frog   498 PPSNVSENTESVSESLTEWEELIKFSTSKALPPI-----------EESYSTIQKSEGSPTTVRKV 551

  Fly   538 EKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPS--PTADRKS 600
            ::|| |..||:|        .|.|.:..|......:..||:|  |....|...:|:  |....:.
 Frog   552 KRPA-PQRPNIP--------PPVQPRANPETAESHSSPKPIP--RRSMSGSLKVPNKPPPHPPQI 605

  Fly   601 TDSIGSFKLKPDV---PQKPL 618
            |.|:|...::|..   |.:||
 Frog   606 TKSLGEGDIEPPTKSPPPRPL 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	48/256 (19%)
		RhoGAP_nadrin	245..452	CDD:239851	73/215 (34%)
		PRK13855	495..>650	CDD:172376	29/129 (22%)
sh3bp1	XP_031756949.1	BAR	16..250	CDD:472257	46/248 (19%)
		RhoGAP	263..462	CDD:470621	70/206 (34%)