DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and FAM13A

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_055698.2	Gene:	FAM13A / 10144	HGNCID:	19367	Length:	1023	Species:	Homo sapiens

Alignment Length:	475	Identity:	112/475 - (23%)
Similarity:	184/475 - (38%)	Gaps:	104/475 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 TEKSRFGTSLK--EHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQH 306
            |.:..||.||:  |....|...|..:|......|.:|||.:|||.||......:.:::...|:
Human    36 TYQKLFGVSLQELERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFES-- 98

  Fly   307 VKTPLPLDYQDPHV--IGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLP 369
             ..|:.|. :|..|  ..|:|||:|||||:.|:|..|...||::.:......:::.::.::.:||
Human    99 -GVPVELG-KDGDVCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELP 161

  Fly   370 KENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAAN 434
            ..:|..|:||.:||:.|.:....|:|:..|||.|..||..        :.|....|.........
Human   162 DTHYCLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCF--------HVPPGLEGMKEQDLCNK 218

  Fly   435 IIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKA 499
            |:.::|            |.|.||.:    ||.....:...|||.|  ..:::...|      |.
Human   219 IMAKIL------------ENYNTLFE----VEYTENDHLRCENLAR--LIIVKEVYY------KN 259

  Fly   500 NAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAASQPTQTQL 564
            :.|         |::|...                 :::.|..||...:|:.:|..:     .|.
Human   260 SLP---------ILLTRGL-----------------ERDMPKPPPKTKIPKSRSEGS-----IQA 293

  Fly   565 EPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGVG 629
            ..:..|.::...|....|     |....:...|..|.:...|.||.|. .|:...|..|..|...
Human   294 HRVLQPELSDGIPQLSLR-----LSYRKACLEDMNSAEGAISAKLVPS-SQEDERPLSPFYLSAH 352

  Fly   630 VPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLDKLRQENGET-----NGTREVSSTTKENN 689
            ||:....|          ||.:....::|...|..|..:....|::     :||...||
Human   353 VPQVSNVS----------ATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASS------ 401

  Fly   690 HNHDPPATAADQNQQQAQPQ 709
                  ||:|.|.::|::.|
Human   402 ------ATSARQRRRQSKEQ 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	6/14 (43%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	57/210 (27%)
FAM13A	NP_055698.2	RhoGAP_FAM13A1a	39..226	CDD:239858	57/210 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..290		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..437		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..562
		HMMR_N	617..>819	CDD:292527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	628..663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..759
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810