DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and arhgap17b

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_009297597.1	Gene:	arhgap17b / 100141341	ZFINID:	ZDB-GENE-080220-26	Length:	790	Species:	Danio rerio

Alignment Length:	801	Identity:	219/801 - (27%)
Similarity:	370/801 - (46%)	Gaps:	144/801 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKL-PALSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||:::..|.....:.:|: ..|.|..|:
Zfish     2 MKKQFNRMKQLANQTVGRAEKTEVLSDDLLLIERRLENVRLVSHNVHKKMVMCLQGNVGT----- 61

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.:||.||.....::|::.|...:|.::..:.|::..||:.|..:|....:.|:..|..::..|
Zfish    62 -DAEKRHKKLPLMILSQSMVEGVAQLGEESLIGKMMDICGDAENKLAFEQSQHEVLLEKDILDPL 125

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK-RSHEA------AIRLEEPAAKVNHIKSQQEECELK 186
            ..:.:.:|..|...:|::::.:.:|.|.| |.|:|      |...:..||||:.:|.:.:|.:.:
Zfish   126 NQLAEVDIPNIQKQRRHLAKLVLDYDSAKGRYHQATKSFPSATNAQAMAAKVDMLKEEMDEAQNR 190

  Fly   187 LEKERDAWAAQMLELIAKEDEIVSCIRDYVL---NQRNYHERALQHVNASLARIQ-DTIQGTEKS 247
            :|..:|..||.|....:||.|..   |.|||   .|..||.|||..:.:.|..|| ...:..||.
Zfish   191 MEICKDQVAADMYSFASKEGEYA---RYYVLLLEAQAEYHRRALASIESVLPNIQSQQDKWMEKP 252

  Fly   248 RFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLP 312
            .|||:|:|||..|.||::..:|.|...|||.|::||||.|:...::||:::|.||:..  .:.|.
Zfish   253 AFGTALEEHLKRTGREVALPIEACVMMLLETGMQEEGLFRIAAGASKLKKLKAALDCS--TSQLE 315

  Fly   313 LDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLR 377
            ..|.|||.:...||.|||||||||::|.||:::|:.:......:|...:..:...|||.|..|.|
Zfish   316 EFYSDPHAVAGALKSYLRELPEPLMSYQLYEEWIQASNISDPDKRLQALWVVCDMLPKANKTNFR 380

  Fly   378 YLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELL 440
            ||.:||:.:...|.:|||::.|:|||:.||:||.:.:.|       :.::.::::.::  |:||:
Zfish   381 YLVKFLAKLALESDVNKMTASNIAIVLGPNLLWAKTEGS-------LAEMAATTSVHVVSIIELI 438

  Fly   441 ISQWDYFFIGEVEF------------------YLTLQKQKLFVEGKSKSNSSNENLDRNDSEVME 487
            |:...:||.|:|:|                  |.|:::::...:|...|:::.::...|......
Zfish   439 INHAGWFFPGDVDFNVSGVFAMPGCPGTPDVEYGTIERRRPGSQGSLDSDTARKDSPANKQPEFA 503

  Fly   488 SPRYGTLRRQKANAPS-----PPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPN 547
            ..|.||:.:::.:.|:     ||...|.|....:.........:.|..|||
Zfish   504 PRRTGTITKKQHSTPNFQPPLPPIEAGGGSAFESCPQLPAAGLEALQTQQT-------------- 554

  Fly   548 LPQFQSPAASQPTQTQLEPLPPPPV----------TPAKPVPMTRTQFFGLDNLPSPTADRKSTD 602
            |.| ||||:...:.:..:.:..||.          ||| |..::..........|||...|:.|
Zfish   555 LVQ-QSPASDNSSLSSRDSVSTPPTMRNGPGGSSGTPA-PAQLSVGTPTSSPKGPSPFMVRRGT- 616

  Fly   603 SIGSFKLKPDVPQKPLLP-KRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLD 666
                 |.:...|.||.:| ..|:|      ||          ||.| .|.|..
Zfish   617 -----KKQAPAPPKPSVPATSPSV------KA----------TPNQ-PISNPY------------ 647

  Fly   667 KLRQENGETNGTREVSSTTKENNH------NHDPPATAAD--QNQQQAQPQ-VTTPISP-----N 717
                   .|.||.:.....:..|.      :|.||...:.  .:.::|.|. ..||..|     :
Zfish   648 -------STPGTPQPLIAPRRTNQTPIQAPSHPPPQPPSQPPSHTEEAVPSPPRTPTPPGTPPHD 705

  Fly   718 SFQTPKRPT-----VPAPPPP 733
            |.|:..|||     .|:.|||
Zfish   706 SSQSRPRPTPRSRPKPSGPPP 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	68/241 (28%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	79/208 (38%)
arhgap17b	XP_009297597.1	BAR_Rich1	14..261	CDD:153302	69/255 (27%)
arhgap17b	XP_009297597.1	RhoGAP_nadrin	250..450	CDD:239851	79/208 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593093
Domainoid	1	1.000	127	1.000	Domainoid score	I5306
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9984
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3190
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm25360
orthoMCL	1	0.900	-	-		OOG6_104723
Panther	1	1.100	-	-	O	PTHR14130
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.750