DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP92B and arhgap22

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_002940376.2	Gene:	arhgap22 / 100127847	XenbaseID:	XB-GENE-5807514	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	124/523 - (23%)
Similarity:	208/523 - (39%)	Gaps:	120/523 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 IAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTEK--------SRFGTSLKEHLT 258
            ::..|::......::|...::||            ::|.::...|        :.||..|::.::
Frog    12 LSSGDKVTVNHETFLLMANSHHE------------MEDWVRAIHKVIWAPFGGAVFGQRLEDAVS 64

  Fly   259 STNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQ-DPHVIG 322
            ...|....:||.|...:.|:||:||||.|:...:|.::.::...::....|   .|.. |.|.:.
Frog    65 LETRHAPLVVEQCVDFIRENGLQEEGLFRLPGQATLVKELQDTFDSGGKPT---FDKSTDVHTVA 126

  Fly   323 SILKLYLRELPEPLLTYNLYKDFIRIAERHS--EAERKTEIKAILTKLPKENYANLRYLTRFLSI 385
            |:|||||||||||::.::.|:||:|.|...|  :.|...|:..::..||..||..|:|:..||..
Frog   127 SLLKLYLRELPEPVIPFSRYQDFLRCAHILSGDQGEGTQELSILIKSLPPVNYNLLKYICSFLDE 191

  Fly   386 VQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIG 450
            ||..|..|||:.||||.|.:||:|.|:       ..|.:..:..:|....::.:||.:..:.|..
Frog   192 VQSYSDTNKMNVQNLATVFAPNILRPK-------QQDPVALIEGASLIQHLLTILIHENHWIFQA 249

  Fly   451 EVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDS-------EVMESPRYGTLRRQKANAPSPPTTN 508
                          |...|....|.:.:|...|       :.:|...:|  ..::..|.|....|
Frog   250 --------------VSADSPVGVSVQQIDNTQSIQDVDTAKSLEPTLHG--NHEQTWAKSQIFAN 298

  Fly   509 GNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNLPQFQSPAAS--QPTQTQLEPLPPPP 571
            .....|.:|       :|.:||...|.           |||    |:.|  |...:.|.......
Frog   299 WKASFMLSS-------SKPVFPSCDPS-----------NLP----PSVSWLQDGFSSLRSHKEKD 341

  Fly   572 VTPAKPVPMTRTQFFGLDNLPS--PTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVLGVGVPKAD 634
            ...|:       :....||:||  |:....:..|..:..|...      |...|...|..|.:..
Frog   342 SVKAQ-------RLSSYDNVPSCLPSLPSSNWSSFSNVSLNES------LCSCPACGGSQVSQGS 393

  Fly   635 ------GKSDDEGGTTPTQATID--------NGNGSVRFKTEHFLDKLRQENGET-NGTREVSST 684
                  ..|:.|.|..|..::|:        :||.          |.|..::||. |..:::.|.
Frog   394 ESGWHLSLSESERGILPLPSSIERLELCVSSSGNS----------DTLTSDSGEVWNTYQKIVSE 448

  Fly   685 TKE 687
            .||
Frog   449 LKE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	9/62 (15%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	69/217 (32%)
arhgap22	XP_002940376.2	PH-like	<16..52	CDD:388408	6/47 (13%)
		RhoGAP	53..247	CDD:383032	67/203 (33%)
		Myosin_tail_1	<446..>521	CDD:366712	3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910