DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP92B and sh3bp1

DIOPT Version :9

Sequence 1:	NP_001287417.1	Gene:	RhoGAP92B / 42371	FlyBaseID:	FBgn0038747	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_001345357.4	Gene:	sh3bp1 / 100006678	ZFINID:	ZDB-GENE-121128-2	Length:	670	Species:	Danio rerio

Alignment Length:	700	Identity:	190/700 - (27%)
Similarity:	313/700 - (44%)	Gaps:	113/700 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRQFAKIKIAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEE 65
            |.:||..:|...........:|....:|..:|::|:..:...:.|.:||.     |...|....:
Zfish     1 MLKQFNILKQFGNGGKSQDATDLLTDDLVLVEQRVEPAKKAAQIIHKKLV-----GCLQSQQGLD 60

  Fly    66 QDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKN 130
            .::|.||.....::.::.||.|:...|..::|||..|..::.|:|:.:.:.|::.|.:|:..|..
Zfish    61 SERRMKKLPLMMLSVSMAESIKDFDGDSSIRKVLEMCCFMQNTLAQTLADFEMKLEKEVLVPLNK 125

  Fly   131 ILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECELKLEKERDAWA 195
            :.::::.||...|:..::...::.:.:...|.:   ..|.||.:.::...||...:||..:|.::
Zfish   126 LSEEDLPEILKNKKQFAKLTTDWNNARTRSETS---TGPQAKQHGLREDVEEAWRRLESIKDQYS 187

  Fly   196 AQMLELIAKEDEIVSCIRDYVLNQRNYH-------ERALQHVNASLARIQDTIQGTEKSRFGTSL 253
            |.:.....|||:..|.....:..|..||       ||.:..:..|.:..:..:..:|...||..|
Zfish   188 ADLYHFATKEDDYASYFTRLLELQAEYHKASYDFLERNITELKESHSHTEPLVSSSENKVFGEPL 252

  Fly   254 KEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDY--- 315
            ..||.|..|:|:..:|.|...||..||.||||.|:..|::.::::|.:|::..|      |:
Zfish   253 LSHLQSCRRKIAVPIEECVNMLLRTGLREEGLFRLAAAASVMKKLKSSLDSGTV------DHTEF 311

  Fly   316 -QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYL 379
             .|||.:...||.|||||||||:|:.||.|:...|......|:...::..|.|||.|||.|||||
Zfish   312 SSDPHAVAGALKCYLRELPEPLMTFELYDDWFEAAGEKETDEKLKLLRTALQKLPTENYNNLRYL 376

  Fly   380 TRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI----IVELL 440
            .:|||.:.:..|:|||:..|:|||:.||:||||.:..::.       ::.:||:::    |:|.|
Zfish   377 IQFLSQLSEHQAVNKMTPSNIAIVLGPNLLWPRCEGETSL-------LDMASASSVQVVTIIEPL 434

  Fly   441 ISQWDYFFIGEVEFYL---------TLQKQKL---------FVEGK---SKSNSSNENLD----- 479
            |......|..|.:|.:         |..::.|         |..|:   ||::||..:.|
Zfish   435 IQHSKSLFPEEADFEVPVLPESPLSTTSQRPLSDSILPSPPFSSGRPSISKTDSSASSDDFGVTI 499

  Fly   480 --------------RNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPH------ 524
                          .|||:..:.|    |.:.......|..|.    ::|.||:...|.
Zfish   500 VVKSAPVNRDAVVWDNDSDPTDQP----LTQDHMPTALPRYTP----VLTPSQSQVMPQISCISE 556

  Fly   525 -AKELFPQQTPEKQEKPAKP-------PLPNLPQ--FQSPAASQPT-QTQLEPLPPPPVTPAKP- 577
             .::|..|:...|...|.||       ..||..:  ..|||.|.|| ||:|.|:|.|..:..||
Zfish   557 PTQDLPTQEPTLKIAGPYKPRRSFIQQKAPNYTKGLLVSPAMSFPTAQTKLPPVPLPRGSEIKPP 621

  Fly   578 -VPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVL 626
             .|...|....|..||.....:|....      :|.||.    |:.|..|
Zfish   622 LSPKPETMLVPLPTLPEGGPPKKPQGR------RPKVPP----PQPPQAL 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_001287417.1	BAR	27..257	CDD:299863	52/236 (22%)
RhoGAP92B	NP_001287417.1	RhoGAP_nadrin	245..452	CDD:239851	81/214 (38%)
sh3bp1	XP_001345357.4	BAR_SH3BP1	12..249	CDD:153304	50/244 (20%)
sh3bp1	XP_001345357.4	RhoGAP	244..446	CDD:295372	81/214 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593091
Domainoid	1	1.000	127	1.000	Domainoid score	I5306
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3190
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000886
OrthoInspector	1	1.000	-	-		otm25360
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14130
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.850