DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Surf6 and RRP14

DIOPT Version :9

Sequence 1:	NP_524408.1	Gene:	Surf6 / 42370	FlyBaseID:	FBgn0038746	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_012841.1	Gene:	RRP14 / 853780	SGDID:	S000001565	Length:	434	Species:	Saccharomyces cerevisiae

Alignment Length:	365	Identity:	99/365 - (27%)
Similarity:	167/365 - (45%)	Gaps:	81/365 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EIEHNKDQKPEKEDLPAITKKFYQRVLELLTIHKVPYSKQEDEETYEEY-LLSDTEESGNKKKKQ 78
            :.:|.|.|| :||   |.:|......|.:.....:..:..||||..|:. ::.|.|  ||:...:
Yeast    87 KFKHMKMQK-QKE---ATSKVEGDSDLNVEVNDPMIIAPDEDEEEEEDIKVIFDDE--GNEIPLE 145

  Fly    79 QGKLKNQDSDDEDVEARIASIKNKLRQKKGPTTER---QQKRRESKKLKRSKGVQKLLLSSAKNL 140
              ..|:....|..||.:..:.:.||::||.....|   |.|..:.|..:::.|.::.:|:..|.
Yeast   146 --SKKDTTEPDRSVEKKSITEEEKLQRKKNLEALRSKLQAKISDMKSKRKAPGSREAILAQRKR- 207

  Fly   141 KNENVKHQKLKN------GVVKSEQETED--------SKEQIQPVKVQPVYNQEAKIVYSKVDF- 190
            |.|..|.::|::      ..:.|:.:.||        ||::.:..|.....|.:. :::..:.|
Yeast   208 KEELKKRKRLESEQEQDQDEIASDSDMEDIDSDLENNSKKRFKKGKKDSEINADG-VMFQNIIFD 271

  Fly   191 --------------AANPGGKAK---KSHQNPKEILKKLRDTKKHLTELREQGETDKAAEIQTDI 238
                          |....|.||   |||       .||.:.||:..|.:::.|..|..|.:
Yeast   272 DGARATSDLQRLRKAGRTKGPAKNDVKSH-------LKLLEAKKNKMEAKDELEQIKQKEKE--- 326

  Fly   239 AWRNAFDKVEGKKVKDDTKLLQKAIKKRRVEKKKSKTKWTERKQKVEHDKEKRQKKRQENL---- 299
            .|:.|..:.||.|::||.|||:||||::..:|:||..:|:|||:.||....:|||:|:|||
Yeast   327 KWQKAMLQAEGIKIRDDEKLLRKAIKRKEAQKRKSAIEWSERKRVVEDTISERQKRREENLRIRK 391

  Fly   300 ----EKRSKDKKNR-----------------KLKTASKRG 318
                :||:|.:|.:                 :|||..|:|
Yeast   392 DNKGKKRNKQEKMKRKYVGSAVPKKRAGFEGRLKTGKKKG 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Surf6	NP_524408.1	SURF6	179..318	CDD:282751	54/181 (30%)
RRP14	NP_012841.1	RRP14	8..58	CDD:406023
RRP14	NP_012841.1	SURF6	221..400	CDD:398547	55/189 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346442
Domainoid	1	1.000	86	1.000	Domainoid score	I1883
eggNOG	1	0.900	-	-		E1_KOG2885
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1499
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100085
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14369
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2266
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.010