Protein Alignment ClpX and CLPX

DIOPT Version :10

• Sequence 1: NP_001287413.1
• Gene: ClpX / 42369
• FlyBaseID: FBgn0038745
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_006651.2
• Gene: CLPX / 10845
• HGNCID: 2088
• Length: 633
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 358/679 - (52%)
• Similarity: 432/679 - (63%)
• Gaps: 111/679 - (16%)

  Fly    26 THGSA--RCVILSAGSAENSDCGVRRFH---LATRNCARNRLMRLEPAMAI---PAYIDVTNAHS 82
            |.|:|  |.:..|..||:....| .|.|   |........::::..|..:.   |||.
Human     8 TCGAAAVRLITSSLASAQRGISG-GRIHMSVLGRLGTFETQILQRAPLRSFTETPAYF------- 64

  Fly    83 RTPEDSSESGSGSEGGASASGGSGAKSPGGAAGSGASSTSGADPPGGGSDKFLSCPKCGSACTQV 147
            .:.:..|:.|||.....|||.||..||..|.:|.|.:.              |.|||||..||.|
Human    65 ASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQ--------------LRCPKCGDLCTHV 115

  Fly   148 ETFVSSTRFVKCAKCNYFFVVLSEVETKQRTKDEPKN---------QRKPPPPPQKIMEYLDKHV 203
            ||||||||||||.||::|||||||.::|:....||::         |:||||||:||..||||:|
Human   116 ETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYV 180

  Fly   204 VGQDFAKKVLAVAVYNHYKRIHHNLPQLQNQGAGASNGAG---GGLDGIPRPD------LLHITG 259
            |||.||||||:||||||||||::|:|....|.|.......   ..|:...|.|      ||.|.|
Human   181 VGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAG 245

  Fly   260 I---GHTLNSSPGNELPPKSPTQMGMGGGMGGPGLGAGLTGASSSNARGGGDNRSGSEILDRQST 321
            |   |:.|.:|...::..:.|.:                              :.|.|:||....
Human   246 ISPHGNALGASMQQQVNQQIPQE------------------------------KRGGEVLDSSHD 280

  Fly   322 DVKLEKSNIIMLGPTGSGKTLIAQTIAKCLDVPFAICDCTTLTQAGYVGEDIESVISKLLQDANY 386
            |:|||||||::||||||||||:|||:||||||||||||||||||||||||||||||:||||||||
Human   281 DIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANY 345

  Fly   387 NVERAQTGIVFLDEVDKIGAVPGIHQLRDVGGEGVQQGMLKMLEGTVVNVPERNSPRKLRGETVQ 451
            |||:||.||||||||||||:||||||||||||||||||:||:||||:|||||:|| |||||||||
Human   346 NVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNS-RKLRGETVQ 409

  Fly   452 VDTTNILFVASGAYTGLDRLIARRLNEKYLGFGMPSTSGSGRRAA-------QSAASPMDNDQEE 509
            |||||||||||||:.||||:|:||.||||||||.||..|.|||||       :|..|....|.||
Human   410 VDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEE 474

  Fly   510 RDKCLTKVQARDLVEFGMIPEFVGRFPVIVPFHSLNVSMLVRILTEPRNALVPQYKALLGLDEVD 574
            :|:.|..|:||||:|||||||||||.||:||.|||:...||:||||||||::|||:||..:|:.:
Human   475 KDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCE 539

  Fly   575 LTFTEDAVKSIAQLAMERHTGARGLRSIMEQLLLDPMFIVPGSDIRGVHITADYVKGSATPEY-- 637
            |..||||:|:||:||:||.|||||||||||:|||:|||.||.|||..|.:..:.|:|...|.|
Human   540 LNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIR 604

  Fly   638 --------------------SRDADAAAS 646
                                .|.||||.|
Human   605 APTKESSEEEYDSGVEEEGWPRQADAANS 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClpX	NP_001287413.1	ClpX	129..637	CDD:440832	322/535 (60%)
CLPX	NP_006651.2	Zn-ribbon	104..132	CDD:445850	22/27 (81%)
		ClpX	172..605	CDD:440832	282/463 (61%)