DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4538 and CLPX

DIOPT Version :9

Sequence 1:NP_001287413.1 Gene:CG4538 / 42369 FlyBaseID:FBgn0038745 Length:679 Species:Drosophila melanogaster
Sequence 2:NP_006651.2 Gene:CLPX / 10845 HGNCID:2088 Length:633 Species:Homo sapiens


Alignment Length:679 Identity:358/679 - (52%)
Similarity:432/679 - (63%) Gaps:111/679 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 THGSA--RCVILSAGSAENSDCGVRRFH---LATRNCARNRLMRLEPAMAI---PAYIDVTNAHS 82
            |.|:|  |.:..|..||:....| .|.|   |........::::..|..:.   |||.       
Human     8 TCGAAAVRLITSSLASAQRGISG-GRIHMSVLGRLGTFETQILQRAPLRSFTETPAYF------- 64

  Fly    83 RTPEDSSESGSGSEGGASASGGSGAKSPGGAAGSGASSTSGADPPGGGSDKFLSCPKCGSACTQV 147
            .:.:..|:.|||.....|||.||..||..|.:|.|.:.              |.|||||..||.|
Human    65 ASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQ--------------LRCPKCGDLCTHV 115

  Fly   148 ETFVSSTRFVKCAKCNYFFVVLSEVETKQRTKDEPKN---------QRKPPPPPQKIMEYLDKHV 203
            ||||||||||||.||::|||||||.::|:....||::         |:||||||:||..||||:|
Human   116 ETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYV 180

  Fly   204 VGQDFAKKVLAVAVYNHYKRIHHNLPQLQNQGAGASNGAG---GGLDGIPRPD------LLHITG 259
            |||.||||||:||||||||||::|:|....|.|.......   ..|:...|.|      ||.|.|
Human   181 VGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAG 245

  Fly   260 I---GHTLNSSPGNELPPKSPTQMGMGGGMGGPGLGAGLTGASSSNARGGGDNRSGSEILDRQST 321
            |   |:.|.:|...::..:.|.:                              :.|.|:||....
Human   246 ISPHGNALGASMQQQVNQQIPQE------------------------------KRGGEVLDSSHD 280

  Fly   322 DVKLEKSNIIMLGPTGSGKTLIAQTIAKCLDVPFAICDCTTLTQAGYVGEDIESVISKLLQDANY 386
            |:|||||||::||||||||||:|||:||||||||||||||||||||||||||||||:||||||||
Human   281 DIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANY 345

  Fly   387 NVERAQTGIVFLDEVDKIGAVPGIHQLRDVGGEGVQQGMLKMLEGTVVNVPERNSPRKLRGETVQ 451
            |||:||.||||||||||||:||||||||||||||||||:||:||||:|||||:|| |||||||||
Human   346 NVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNS-RKLRGETVQ 409

  Fly   452 VDTTNILFVASGAYTGLDRLIARRLNEKYLGFGMPSTSGSGRRAA-------QSAASPMDNDQEE 509
            |||||||||||||:.||||:|:||.||||||||.||..|.|||||       :|..|....|.||
Human   410 VDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEE 474

  Fly   510 RDKCLTKVQARDLVEFGMIPEFVGRFPVIVPFHSLNVSMLVRILTEPRNALVPQYKALLGLDEVD 574
            :|:.|..|:||||:|||||||||||.||:||.|||:...||:||||||||::|||:||..:|:.:
Human   475 KDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCE 539

  Fly   575 LTFTEDAVKSIAQLAMERHTGARGLRSIMEQLLLDPMFIVPGSDIRGVHITADYVKGSATPEY-- 637
            |..||||:|:||:||:||.|||||||||||:|||:|||.||.|||..|.:..:.|:|...|.|  
Human   540 LNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIR 604

  Fly   638 --------------------SRDADAAAS 646
                                .|.||||.|
Human   605 APTKESSEEEYDSGVEEEGWPRQADAANS 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4538NP_001287413.1 ClpX 140..638 CDD:224140 319/547 (58%)
AAA_2 327..537 CDD:285025 171/216 (79%)
ClpB_D2-small 544..631 CDD:198154 53/86 (62%)
CLPXNP_006651.2 clpX 102..600 CDD:273047 321/542 (59%)
Zn-ribbon 104..132 CDD:295390 22/27 (81%)
AAA_2 286..502 CDD:285025 171/216 (79%)
ClpB_D2-small 509..603 CDD:198154 55/93 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159013
Domainoid 1 1.000 344 1.000 Domainoid score I1057
eggNOG 1 0.900 - - E1_COG1219
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4851
Inparanoid 1 1.050 617 1.000 Inparanoid score I900
Isobase 1 0.950 - 0 Normalized mean entropy S1175
OMA 1 1.010 - - QHG49224
OrthoDB 1 1.010 - - D1040247at2759
OrthoFinder 1 1.000 - - FOG0002664
OrthoInspector 1 1.000 - - oto89216
orthoMCL 1 0.900 - - OOG6_101643
Panther 1 1.100 - - LDO PTHR48102
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2184
SonicParanoid 1 1.000 - - X1775
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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