DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4733 and ppp2r3b

DIOPT Version :9

Sequence 1:	NP_001247197.1	Gene:	CG4733 / 42368	FlyBaseID:	FBgn0038744	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_001072674.1	Gene:	ppp2r3b / 780131	XenbaseID:	XB-GENE-1012645	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	448	Identity:	233/448 - (52%)
Similarity:	311/448 - (69%)	Gaps:	26/448 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 PQTDPPPKSLMKVKLHATPPP----------PPQEQNLLQKEIRSTKSVYIPRFYFPHGKPQPNI 508
            ||:..||.|....:...||..          |.:|:.|     ....|..||:||||.|.|:.|:
Frog    77 PQSALPPGSYGSPRSGLTPRKRRSSSVGVVHPKKEEPL-----TPALSQNIPKFYFPKGCPKANL 136

  Fly   509 AMERVVRGILSAFDSFPNNQVTKDELPRILKICGLPFYWRMPVMVFCQSASTGLVERQRFVEFWK 573
            .::.::..|...|..||..:.|.:::.::.|.|..|.||:.|:........||.|...:|:..|:
Frog   137 NIDGIISKIEKTFSGFPLERATLEDMGKVAKACECPLYWKAPLFYAAGGERTGYVSVHKFIAMWR 201

  Fly   574 QMNVYCHEAASRFVYILSRGQRFRSYIVPEDLVPMVQDVVDTHPGLAFLKEATEFHSRYVHTVIA 638
            ::...||:.|::|:.:|::..  .||:..||.:|.:||||:|||.|.||:||:||||||:.||:.
Frog   202 KILHTCHDDAAKFMQLLAKPG--CSYLEQEDFIPFLQDVVNTHPHLTFLREASEFHSRYITTVVQ 264

  Fly   639 RIFYSVNRSWSGKITIAELKRSDLLEMISLLEEEEDINQIMAFFSYEHFYVIYCKFWELDKDHDL 703
            ||||.|||||||:||.:||::|:.|:.::|| |||||||...:|||||||||||||||||.||||
Frog   265 RIFYLVNRSWSGRITCSELRKSNFLQHVALL-EEEDINQSADYFSYEHFYVIYCKFWELDTDHDL 328

  Fly   704 LINQEDLAKHSDHALSSRIVERIFSGCVTRSDNKKAPEDEAKMSYTDFVWFILSEEDKRTPTAIE 768
            .|::.|||||:|||:||.:::|||||.||||   :....|.|:||.|||||:||||||:|.|:||
Frog   329 YIDENDLAKHNDHAISSHVIQRIFSGTVTRS---RKVHKEGKISYADFVWFLLSEEDKKTQTSIE 390

  Fly   769 YWFRCMDVDGDGVLSMYELEYFYEEQQQRMEGIGIECLPFEDCLCQMLDMIKPANRDCITLGDLK 833
            |||||||:||||||||||||||||||.|:||.:.||.||||||||||||::||.....|||.|||
Frog   391 YWFRCMDLDGDGVLSMYELEYFYEEQCQKMESMAIEPLPFEDCLCQMLDLVKPQTEGKITLHDLK 455

  Fly   834 RCKMTHVFFDTFFNLEKYLDHEQRDPFASQR-----DEYTSDWDRFAAQEYELLISEE 886
            :||..::|||||.||||||||||:|||:..|     .:..|||:::||:||.:|::||
Frog   456 KCKQANIFFDTFLNLEKYLDHEQKDPFSVLRVGENEGQELSDWEKYAAEEYAVLVAEE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4733	NP_001247197.1	EF-hand_7	690..791	CDD:290234	72/100 (72%)
ppp2r3b	NP_001072674.1	EF-hand_13	209..298	CDD:375447	48/91 (53%)
ppp2r3b	NP_001072674.1	EF-hand_7	312..413	CDD:372618	75/103 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3650
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H61474
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001858
OrthoInspector	1	1.000	-	-		otm48692
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5283
SonicParanoid	1	1.000	-	-		X1783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030