DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4733 and PPP2R3A

DIOPT Version :9

Sequence 1:	NP_001247197.1	Gene:	CG4733 / 42368	FlyBaseID:	FBgn0038744	Length:	888	Species:	Drosophila melanogaster
Sequence 2:	NP_002709.2	Gene:	PPP2R3A / 5523	HGNCID:	9307	Length:	1150	Species:	Homo sapiens

Alignment Length:	965	Identity:	346/965 - (35%)
Similarity:	475/965 - (49%)	Gaps:	173/965 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KTKKLSSGTGTNMISSVAV---------TSAIKTTTTTRKPAGSGVSSKVSKAQGATNSTPASSD 70
            |....||||...|...:.:         |..||  ...:|.:||.:|      :|:.|.|.:||:
Human   219 KIDNFSSGTDIKMCLDILLKCSEDLKKCTDIIK--QCIKKKSGSSIS------EGSGNDTISSSE 275

  Fly    71 S-----NAEIAELTKKINDHADAIYHTWKSQGIPPTELLTMYTSAAASGDLADVASPTADAEGLQ 130
            :     ...:|...||:   ......:..::.:..|||::...|...:     ..||....|...
Human   276 TVYMNVMTRLASYLKKL---PFEFMQSGNNEALDLTELISNMPSLQLT-----PFSPVFGTEQPP 332

  Fly   131 KMVTSFVNKDKEQRGKSNTLKKSDITTANGKVKKAAVSSFSPVPDQALQS--------PKKVAAV 187
            |.      :|..|...|::.:...|...|.|.....:.:...:|:.:..|        |:.:.||
Human   333 KY------EDVVQLSASDSGRFQTIELQNDKPNSRKMDTVQSIPNNSTNSLYNLEVNDPRTLKAV 391

  Fly   188 TVSKPLPDVNLNYDISLDLDVNNLSSQQTQNLLKISELIQQQKDVAATVGKKRQNSKANSSSSIN 252
            .|......:|         .:.|:||......|.|.|....:|  |...|:|.:|..::....:|
Human   392 QVQSQSLTMN---------PLENVSSDDLMETLYIEEESDGKK--ALDKGQKTENGPSHELLKVN 445

  Fly   253 --------------------SNHIGNSASSNKLTASEQPTKKQSKANSSGSTRTGSAAVSLDVVD 297
                                .|.||.....:.:...::..|.:......|..|..:.:.|.:.:|
Human   446 EHRAEFPEHATHLKKCPTPMQNEIGKIFEKSFVNLPKEDCKSKVSKFEEGDQRDFTNSSSQEEID 510

  Fly   298 GPSAARIANSTAVSDKGGEPAATGSRK------SSKTKETSAD-------SKPATKEKPTAVATV 349
            .......:.|..:.....||.|.|...      |..|.:|..|       |.|..|..|:.:..:
Human   511 KLLMDLESFSQKMETSLREPLAKGKNSNFLNSHSQLTGQTLVDLEPKSKVSSPIEKVSPSCLTRI 575

  Fly   350 --ANARKSTS-------RI---ATDNAGNMAAATAAAAATS-------ATSAATATSMDATPATA 395
              .|..|...       ||   ..|.|..:....::..:.|       .......||..|..:..
Human   576 IETNGHKIEEEDRALLLRILESIEDFAQELVECKSSRGSLSQEKEMMQILQETLTTSSQANLSVC 640

  Fly   396 ASTTMPTLNKVKPTSGARAALANGQDKMNLLTRGSVAERVLMFEKCPDVRHAFLNI-----KRPQ 455
            .|   |..:|.|.|:.|                       ::.::.|:|    :.|     |:|.
Human   641 RS---PVGDKAKDTTSA-----------------------VLIQQTPEV----IKIQNKPEKKPG 675

  Fly   456 TD-PPPKSLMKVKLHATPP-------PPPQEQNLLQKEIRSTKSVYIPRFYFPHGKPQPNIAMER 512
            |. |||         ||.|       |.|...|:    :.:..|:.|||||||.|.|......|:
Human   676 TPLPPP---------ATSPSSPRPLSPVPHVNNV----VNAPLSINIPRFYFPEGLPDTCSNHEQ 727

  Fly   513 VVRGILSAFDSFPNNQVTKDELPRILKICGLPFYWRMPVMVFCQSASTGLVERQRFVEFWKQMNV 577
            .:..|.:||......:....|:.:|.|:||.|.||:.|:........||.|..|.|:..|:::..
Human   728 TLSRIETAFMDIEEQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQSFIAMWRKLLN 792

  Fly   578 YCHEAASRFVYILSRGQRFRSYIVPEDLVPMVQDVVDTHPGLAFLKEATEFHSRYVHTVIARIFY 642
            ..|:.||:|:.:|::..  .|.:..||.:|::||||||||||.|||:|.||||||:.|||.||||
Human   793 NHHDDASKFICLLAKPN--CSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFY 855

  Fly   643 SVNRSWSGKITIAELKRSDLLEMISLLEEEEDINQIMAFFSYEHFYVIYCKFWELDKDHDLLINQ 707
            :||||||||||..|:::|:.|:.::|||||||||||..:|||||||||||||||||.||||.|:|
Human   856 TVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDTDHDLYISQ 920

  Fly   708 EDLAKHSDHALSSRIVERIFSGCVTRSDNKKAPEDEAKMSYTDFVWFILSEEDKRTPTAIEYWFR 772
            .||::::|.|.||||:||||||.|||.   |..:.|.:|||.|||||::||||||.||:||||||
Human   921 ADLSRYNDQASSSRIIERIFSGAVTRG---KTIQKEGRMSYADFVWFLISEEDKRNPTSIEYWFR 982

  Fly   773 CMDVDGDGVLSMYELEYFYEEQQQRMEGIGIECLPFEDCLCQMLDMIKPANRDCITLGDLKRCKM 837
            ||||||||||||||||||||||.:|||.:|||.|||.|.||||||::|||....|||.|||||:|
Human   983 CMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRM 1047

  Fly   838 THVFFDTFFNLEKYLDHEQRDPFASQRD-----EYTSDWDRFAAQEYELLISEEN 887
            .|:|:|||||||||||||||||||.|:|     ...||||||||:|||.|::||:
Human  1048 AHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEES 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4733	NP_001247197.1	EF-hand_7	690..791	CDD:290234	73/100 (73%)
PPP2R3A	NP_002709.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..693		12/44 (27%)
		EF-hand_7	903..1001	CDD:290234	73/100 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1132
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I3728
eggNOG	1	0.900	-	-		E1_KOG2562
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001858
OrthoInspector	1	1.000	-	-		otm41482
orthoMCL	1	0.900	-	-		OOG6_101579
Panther	1	1.100	-	-	O	PTHR14095
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770