DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and OPN1MW2

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001041646.1	Gene:	OPN1MW2 / 728458	HGNCID:	26952	Length:	364	Species:	Homo sapiens

Alignment Length:	336	Identity:	103/336 - (30%)
Similarity:	156/336 - (46%)	Gaps:	35/336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PIWAKILTA-YMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGIN 110
            |.|...||: :||.:.:.|...||:|:......|.||.|.|.:::|||::|....:..:.:..:|
Human    49 PRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVN 113

  Fly   111 LYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWF 175
            ..:..:|||..||.:.....|..|.:.:||:.:||.:|:.|:.|..........||:..||:.|.
Human   114 QVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWI 178

  Fly   176 MSSIWCLAPAFGWSRYVPEGNLTSCGIDYLERDWNP--RSYLIFYSIFVYYIPLFLI--CY-SYW 235
            .:::|...|.||||||.|.|..||||.|.......|  :||:|...:.....||.:|  || ..|
Human   179 WAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVW 243

  Fly   236 FIIAAVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGL 300
            ..|.||:..:|               .||..:| ||.::.::.:|.:..:...|.||....|...
Human   244 LAIRAVAKQQK---------------ESESTQK-AEKEVTRMVVVMVLAFCFCWGPYAFFACFAA 292

  Fly   301 ----FKFEGLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFG-KVDDGKSSDA 360
                :.|.   ||.....|.|||||..|||::|...:.::|     .|...:|| |||||....:
Human   293 ANPGYPFH---PLMAALPAFFAKSATIYNPVIYVFMNRQFR-----NCILQLFGKKVDDGSELSS 349

  Fly   361 QSQATASEAES 371
            .|:...|...|
Human   350 ASKTEVSSVSS 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	90/297 (30%)
		TM helix 1	53..77	CDD:320207	8/24 (33%)
		TM helix 2	86..108	CDD:320207	5/21 (24%)
		TM helix 3	124..146	CDD:320207	5/21 (24%)
		TM helix 4	168..184	CDD:320207	4/15 (27%)
		TM helix 5	212..235	CDD:320207	8/25 (32%)
		TM helix 6	275..297	CDD:320207	4/21 (19%)
		TM helix 7	308..333	CDD:320207	12/24 (50%)
OPN1MW2	NP_001041646.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269\|PubMed:30948514	17..43
		7tm_4	61..>178	CDD:304433	33/116 (28%)
		7tm_1	71..322	CDD:278431	83/269 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910