Protein Alignment ninaE and HCRTR2

DIOPT Version :10

• Sequence 1: NP_524407.1
• Gene: ninaE / 42367
• FlyBaseID: FBgn0002940
• Length: 373
• Species: Drosophila melanogaster
• Sequence 2: XP_016866287.1
• Gene: HCRTR2 / 3062
• HGNCID: 4849
• Length: 461
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 83/427 - (19%)
• Similarity: 156/427 - (36%)
• Gaps: 102/427 - (23%)

  Fly    17 PLSNGSVVDKVTPDMAHLISP-----------YWNQFPAMDP---IWAKILTAYMIMIGMISWCG 67
            |..|.|...::.......::|           .|.::  :.|   .|  :|.|..|::.:::..|
Human    11 PCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREY--LHPKEYEW--VLIAGYIIVFVVALIG 71

  Fly    68 NGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGINLYFETWVLGPMMCDIYAGLGSA 132
            |.:|.........:||..|..::||:::|..:.||..|...:....|||..|..:|.:...|.:.
Human    72 NVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTV 136

  Fly   133 FGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNL 197
            ....|:.::..|:|||:..|...:..: .|...|...|..||.:|   |:.       .:|:..:
Human   137 SVSVSVLTLSCIALDRWYAICHPLMFK-STAKRARNSIVIIWIVS---CII-------MIPQAIV 190

  Fly   198 TSCGIDY------------LERDWN----PRSYLIFYSIFVYYIPLFLICYSY------------ 234
            ..|...:            .:..|.    |:.|.|.:.:..|..||.|:..:|
Human   191 MECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQI 255

  Fly   235 ----------WFIIAAVS-----AHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITL 284
                      |..:..||     ......|..|....:|.:|        |..|.|::.::.:.:
Human   256 PGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIR--------ARRKTARMLMIVLLV 312

  Fly   285 WFMAWTPYLVINCM----GLFKFEGLTPLNTIWG-------ACFAKSAACYNPIVYGISHPKYRL 338
            :.:.:.|..::|.:    |:|..  .....|::.       ..:|.|||  |||:|.....|:|.
Human   313 FAICYLPISILNVLKRVFGMFAH--TEDRETVYAWFTFSHWLVYANSAA--NPIIYNFLSGKFRE 373

  Fly   339 ALKEKCPCCVFG-------KVDDGKSSDAQSQATASE 368
            ..|....||..|       ::..|::|....::..::
Human   374 EFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQ 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	70/341 (21%)
		TM helix 1	52..78	CDD:320207	6/25 (24%)
		TM helix 2	85..111	CDD:320207	7/25 (28%)
		TM helix 3	123..153	CDD:320207	7/29 (24%)
		TM helix 4	164..184	CDD:320207	6/19 (32%)
		TM helix 5	211..240	CDD:320207	9/50 (18%)
		TM helix 6	269..299	CDD:320207	5/33 (15%)
		TM helix 7	308..333	CDD:320207	9/31 (29%)
HCRTR2	XP_016866287.1	7tmA_OXR	55..375	CDD:320336	71/344 (21%)
		TM helix 1	56..82	CDD:320336	6/25 (24%)
		TM helix 2	89..115	CDD:320336	7/25 (28%)
		TM helix 3	127..157	CDD:320336	7/29 (24%)
		TM helix 4	168..189	CDD:320336	7/30 (23%)
		TM helix 5	220..249	CDD:320336	8/28 (29%)
		TM helix 6	297..327	CDD:320336	6/37 (16%)
		TM helix 7	343..368	CDD:320336	8/26 (31%)
		Orexin_rec2	387..444	CDD:427531	2/24 (8%)