DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and rho

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_571159.1	Gene:	rho / 30295	ZFINID:	ZDB-GENE-990415-271	Length:	354	Species:	Danio rerio

Alignment Length:	373	Identity:	106/373 - (28%)
Similarity:	188/373 - (50%)	Gaps:	46/373 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GPHF-APLSNGSVVDKVTPDMAHLISPY-WNQFPAMDPIWA-KILTAYMIMIGMISWCGNGVVIY 73
            ||.| .|:||.:.|.:         ||| :.|:..:.| || ..:.|||..:.:..:..|.:.:|
Zfish     6 GPAFYVPMSNATGVVR---------SPYEYPQYYLVAP-WAYGFVAAYMFFLIITGFPVNFLTLY 60

  Fly    74 IFATTKSLRTPANLLVINLAISDFGIM---ITNTPMMGINLYFETWVLGPMMCDI---YAGLGSA 132
            :....|.||||.|.:::||||:|..::   .|.|....::.||   |.|.:.|::   :|.||..
Zfish    61 VTIEHKKLRTPLNYILLNLAIADLFMVFGGFTTTMYTSLHGYF---VFGRLGCNLEGFFATLGGE 122

  Fly   133 FGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNL 197
            .|   :.|:.:::::|:.|:.|.::........|:..:|:.|.|:....:.|..|||||:|||..
Zfish   123 MG---LKSLVVLAIERWMVVCKPVSNFRFGENHAIMGVAFTWVMACSCAVPPLVGWSRYIPEGMQ 184

  Fly   198 TSCGIDYLER--DWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSL 260
            .|||:||..|  ..|..|::|:..|..::|||.:|.:.|..::..|   ::|.|:|
Zfish   185 CSCGVDYYTRTPGVNNESFVIYMFIVHFFIPLIVIFFCYGRLVCTV---KEAARQQ--------- 237

  Fly   261 RSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG--LTPLNTIWGACFAKSAAC 323
            :.||..:: ||.::.::.::.:..:.:.|.||..: ...:|..:|  ..|:.....|.|||::|.
Zfish   238 QESETTQR-AEREVTRMVIIMVIAFLICWLPYAGV-AWYIFTHQGSEFGPVFMTLPAFFAKTSAV 300

  Fly   324 YNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKSSDAQSQATASEAES 371
            |||.:|...:.::|..:.... ||  ||....:...|.:.|:.:||.|
Zfish   301 YNPCIYICMNKQFRHCMITTL-CC--GKNPFEEEEGASTTASKTEASS 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	83/297 (28%)
		TM helix 1	53..77	CDD:320207	5/23 (22%)
		TM helix 2	86..108	CDD:320207	8/24 (33%)
		TM helix 3	124..146	CDD:320207	5/24 (21%)
		TM helix 4	168..184	CDD:320207	3/15 (20%)
		TM helix 5	212..235	CDD:320207	7/22 (32%)
		TM helix 6	275..297	CDD:320207	3/21 (14%)
		TM helix 7	308..333	CDD:320207	10/24 (42%)
rho	NP_571159.1	Rhodopsin_N	2..37	CDD:287397	13/40 (33%)
		7tm_4	45..323	CDD:304433	80/298 (27%)
		7tm_1	55..306	CDD:278431	78/270 (29%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000250\|UniProtKB:P02699	134..136		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354		5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910