Protein Alignment ninaE and Hrh2

DIOPT Version :10

• Sequence 1: NP_524407.1
• Gene: ninaE / 42367
• FlyBaseID: FBgn0002940
• Length: 373
• Species: Drosophila melanogaster
• Sequence 2: NP_001399940.1
• Gene: Hrh2 / 25461
• RGDID: 2831
• Length: 402
• Species: Rattus norvegicus
• Alignment Length: 344
• Identity: 86/344 - (25%)
• Similarity: 152/344 - (44%)
• Gaps: 42/344 - (12%)

  Fly    45 MDPIWAKI-LTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMG 108
            :|.:..|: ::..:..:.:|:..||.||....:..:.||:..|..:::||.:|..:.:...|...
  Rat    12 LDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSA 76

  Fly   109 INLYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALG-KIAY 172
            |......|..|.:.|:||..|......:||.::.|||||||..:...:....:..|:.:. .:.:
  Rat    77 IYQLSFKWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVF 141

  Fly   173 IWFMS-SIWCLAPAFGW-SRYVPEG--NLTSCGIDYLERDWNPRSYLIFYSIFVYYIPLFLICYS 233
            ||.:| ::..|:...|| ||....|  :...|.:...|      .|.:...:..:|:||.::|.:
  Rat   142 IWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNE------VYGLVDGLVTFYLPLLIMCVT 200

  Fly   234 YWFIIAAVSAHEKAMREQAKKMN-VKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINC 297
            |:.|.       |..|||||::| :.|.:::...|..|...||.|....|..||    ||..
  Rat   201 YYRIF-------KIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWF----PYFT--- 251

  Fly   298 MGLFKFEGL---TPLN------TIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVD 353
              .|.:.||   ..:|      .:| ..:|.||  .|||:|...:..:|.|.::... |.|...:
  Rat   252 --AFVYRGLRGDDAINEAVEGIVLW-LGYANSA--LNPILYAALNRDFRTAYQQLFH-CKFASHN 310

  Fly   354 DGKSSDAQSQATASEAESK 372
            ..|:|...:.:....::|:
  Rat   311 SHKTSLRLNNSLLPRSQSR 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	78/303 (26%)
		TM helix 1	52..78	CDD:320207	5/26 (19%)
		TM helix 2	85..111	CDD:320207	6/25 (24%)
		TM helix 3	123..153	CDD:320207	13/29 (45%)
		TM helix 4	164..184	CDD:320207	5/21 (24%)
		TM helix 5	211..240	CDD:320207	7/28 (25%)
		TM helix 6	269..299	CDD:320207	9/29 (31%)
		TM helix 7	308..333	CDD:320207	9/30 (30%)
Hrh2	NP_001399940.1	7tmA_Histamine_H2R	19..298	CDD:320179	78/303 (26%)
		TM helix 1	20..46	CDD:320179	5/25 (20%)
		TM helix 2	53..80	CDD:320179	6/26 (23%)
		TM helix 3	91..121	CDD:320179	13/29 (45%)
		TM helix 4	133..153	CDD:320179	3/19 (16%)
		TM helix 5	178..208	CDD:320179	9/42 (21%)
		TM helix 6	226..256	CDD:320179	11/38 (29%)
		TM helix 7	266..291	CDD:320179	8/27 (30%)