DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and Rho

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	XP_038962987.1	Gene:	Rho / 24717	RGDID:	3573	Length:	358	Species:	Rattus norvegicus

Alignment Length:	384	Identity:	108/384 - (28%)
Similarity:	189/384 - (49%)	Gaps:	61/384 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GPHF-APLSNGSVVDKVTPDMAHLISPYWN-QFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYI 74
            ||:| .|.||.:.|.:         ||:.. |:...:|....:|.|||.::.::.:..|.:.:|:
  Rat     6 GPNFYVPFSNITGVVR---------SPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYV 61

  Fly    75 FATTKSLRTPANLLVINLAISDFGIM---ITNTPMMGINLYFETWVLGPMMCDI---YAGLGSAF 133
            ....|.||||.|.:::|||::|..::   .|.|....::.||   |.||..|::   :|.||...
  Rat    62 TVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYF---VFGPTGCNLEGFFATLGGEI 123

  Fly   134 GCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWS--------- 189
            |   :||:.:::::||.|:.|.|:........|:..:|:.|.|:......|..|||
  Rat   124 G---LWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSSVFSPCFIT 185

  Fly   190 -RYVPEGNLTSCGIDY--LERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQ 251
             ||:|||...||||||  |:.:.|..|::|:..:..:.||:.:|.:.|..::..|.  |.|.::|
  Rat   186 LRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVK--EAAAQQQ 248

  Fly   252 AKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG--LTPLNTIWG 314
            ......|           ||.::.::.::.:..:.:.|.||..: .|.:|..:|  ..|:.....
  Rat   249 ESATTQK-----------AEKEVTRMVIIMVIFFLICWLPYASV-AMYIFTHQGSNFGPIFMTLP 301

  Fly   315 ACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFGKVDDGKS--SDAQSQATASEAES 371
            |.|||:|:.||||:|.:.:.::|..:.... ||       ||:  .|.::.||||:.|:
  Rat   302 AFFAKTASIYNPIIYIMMNKQFRNCMLTTL-CC-------GKNPLGDDEASATASKTET 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	87/307 (28%)
		TM helix 1	53..77	CDD:320207	6/23 (26%)
		TM helix 2	86..108	CDD:320207	7/24 (29%)
		TM helix 3	124..146	CDD:320207	6/24 (25%)
		TM helix 4	168..184	CDD:320207	3/15 (20%)
		TM helix 5	212..235	CDD:320207	5/22 (23%)
		TM helix 6	275..297	CDD:320207	3/21 (14%)
		TM helix 7	308..333	CDD:320207	11/24 (46%)
Rho	XP_038962987.1	Rhodopsin_N	3..37	CDD:313611	11/39 (28%)
		7tmA_MWS_opsin	38..327	CDD:381742	87/308 (28%)
		TM helix 1	40..64	CDD:381742	6/23 (26%)
		TM helix 2	73..95	CDD:381742	6/21 (29%)
		TM helix 3	111..133	CDD:381742	6/24 (25%)
		TM helix 4	155..171	CDD:381742	3/15 (20%)
		TM helix 5	211..234	CDD:381742	5/22 (23%)
		TM helix 6	261..283	CDD:381742	3/22 (14%)
		TM helix 7	295..320	CDD:381742	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910