DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and Rho

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_663358.1	Gene:	Rho / 212541	MGIID:	97914	Length:	348	Species:	Mus musculus

Alignment Length:	374	Identity:	105/374 - (28%)
Similarity:	187/374 - (50%)	Gaps:	51/374 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GPHF-APLSNGSVVDKVTPDMAHLISPYWN-QFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYI 74
            ||:| .|.||.:.|.:         ||:.. |:...:|....:|.|||.::.::.:..|.:.:|:
Mouse     6 GPNFYVPFSNVTGVVR---------SPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYV 61

  Fly    75 FATTKSLRTPANLLVINLAISDFGIM---ITNTPMMGINLYFETWVLGPMMCDI---YAGLGSAF 133
            ....|.||||.|.:::|||::|..::   .|.|....::.||   |.||..|::   :|.||
Mouse    62 TVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYF---VFGPTGCNLEGFFATLG--- 120

  Fly   134 GCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLT 198
            |..::||:.:::::||.|:.|.|:........|:..:.:.|.|:......|..|||||:|||...
Mouse   121 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVVFTWIMALACAAPPLVGWSRYIPEGMQC 185

  Fly   199 SCGIDY--LERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLR 261
            ||||||  |:.:.|..|::|:..:..:.||:.:|.:.|..::..|.  |.|.::|......|
Mouse   186 SCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVK--EAAAQQQESATTQK--- 245

  Fly   262 SSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEG--LTPLNTIWGACFAKSAACY 324
                    ||.::.::.::.:..:.:.|.||..: ...:|..:|  ..|:.....|.||||::.|
Mouse   246 --------AEKEVTRMVIIMVIFFLICWLPYASV-AFYIFTHQGSNFGPIFMTLPAFFAKSSSIY 301

  Fly   325 NPIVYGISHPKYRLALKEKCPCCVFGKVDDGKS--SDAQSQATASEAES 371
            ||::|.:.:.::|..:.... ||       ||:  .|..:.||||:.|:
Mouse   302 NPVIYIMLNKQFRNCMLTTL-CC-------GKNPLGDDDASATASKTET 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	84/297 (28%)
		TM helix 1	53..77	CDD:320207	6/23 (26%)
		TM helix 2	86..108	CDD:320207	7/24 (29%)
		TM helix 3	124..146	CDD:320207	6/24 (25%)
		TM helix 4	168..184	CDD:320207	2/15 (13%)
		TM helix 5	212..235	CDD:320207	5/22 (23%)
		TM helix 6	275..297	CDD:320207	3/21 (14%)
		TM helix 7	308..333	CDD:320207	10/24 (42%)
Rho	NP_663358.1	Rhodopsin_N	3..37	CDD:313611	11/39 (28%)
		7tmA_MWS_opsin	38..317	CDD:320208	84/298 (28%)
		TM helix 1	39..65	CDD:320208	6/25 (24%)
		TM helix 2	72..99	CDD:320208	7/26 (27%)
		TM helix 3	110..140	CDD:320208	10/32 (31%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000250\|UniProtKB:P02699	134..136		0/1 (0%)
		TM helix 4	151..173	CDD:320208	4/21 (19%)
		TM helix 5	200..230	CDD:320208	6/29 (21%)
		TM helix 6	245..275	CDD:320208	6/41 (15%)
		TM helix 7	285..310	CDD:320208	10/24 (42%)
		Interaction with SAG. /evidence=ECO:0000250\|UniProtKB:P02699	330..348		6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910