DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and tkr-1

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_499064.2	Gene:	tkr-1 / 192055	WormBaseID:	WBGene00006576	Length:	406	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	79/359 - (22%)
Similarity:	145/359 - (40%)	Gaps:	68/359 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ESFAVAAAQLGPHF-APLSNGSVVDKVTPDMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISW 65
            |:..:.|...|..| ||.|..|:..:|...:|.:                 :|.|..|:
Worm    18 ENLTLPAELEGIFFCAPSSRESLATQVFVAIAFV-----------------LLMATAII------ 59

  Fly    66 CGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNT-PMMGINLYFETWVLGPMMCDIYAGL 129
             ||.||::|....|.:....|..:.|:|.:|..|.:.|. .....|||::.| .|. :|.:.:..
Worm    60 -GNSVVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVGTSWTYNLYYDWW-YGD-LCTLTSFF 121

  Fly   130 GSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWFMSSIWCLAPAFGWS----- 189
            |.|....|:.||..:|.||.|.:|..:..||::...::..|..||.:|::..|..|...|
Worm   122 GIAPTTVSVCSMMALSWDRCQAVVNPLQKRPLSRKRSVIAILIIWVVSTVTALPFAIAASVNSLY 186

  Fly   190 ------RYVPEGNLTSCGID-YLERDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA 247
                  ..|.:.::.|..:: :.|:        :.:.| .|.:|:.::..::..|..|..|..:|
Worm   187 TYDVVTSTVSKAHVCSAPVNTFFEK--------VLFGI-QYALPIIILGSTFTRIAVAFRATNEA 242

  Fly   248 MREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGLFKFEGLTP---- 308
            .....|..:.:           |:.|..|:..:.:..:.:.|.||.:.:...|.:|.....
Worm   243 TDSSLKNNHTR-----------AKSKAVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDAARGKYA 296

  Fly   309 -LNTIWGACFAKSAACYNPIVYGISHPKYRLALK 341
             |...|   .|.|:..||||:|..::.::|:..:
Worm   297 YLLIYW---IAMSSCAYNPIIYCFANERFRIGFR 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	69/305 (23%)
		TM helix 1	53..77	CDD:320207	8/23 (35%)
		TM helix 2	86..108	CDD:320207	6/22 (27%)
		TM helix 3	124..146	CDD:320207	5/21 (24%)
		TM helix 4	168..184	CDD:320207	5/15 (33%)
		TM helix 5	212..235	CDD:320207	3/22 (14%)
		TM helix 6	275..297	CDD:320207	4/21 (19%)
		TM helix 7	308..333	CDD:320207	9/29 (31%)
tkr-1	NP_499064.2	7tm_4	58..330	CDD:304433	67/302 (22%)
tkr-1	NP_499064.2	7tm_1	60..315	CDD:278431	64/279 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6735
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860