DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ninaE and Opn1mw

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_032132.1	Gene:	Opn1mw / 14539	MGIID:	1097692	Length:	359	Species:	Mus musculus

Alignment Length:	336	Identity:	102/336 - (30%)
Similarity:	156/336 - (46%)	Gaps:	35/336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PIWAKILTA-YMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITNTPMMGIN 110
            |.|...||: :||::.:.|...||:|:......|.||.|.|.:::|||::|....|..:.:..:|
Mouse    44 PRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVN 108

  Fly   111 LYFETWVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAGRPMTIPLALGKIAYIWF 175
            ..:..:|||..:|.|...:.|..|.:.:||:.:||.:|:.|:.|..........||...|.:.|.
Mouse   109 QIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWV 173

  Fly   176 MSSIWCLAPAFGWSRYVPEGNLTSCGIDYLERDWNP--RSYLIFYSIFVYYIPLFLI--CY-SYW 235
            .::||...|.||||||.|.|..||||.|.......|  :||::...:.....||.:|  || ..|
Mouse   174 WAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVW 238

  Fly   236 FIIAAVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAKVALVTITLWFMAWTPYLVINCMGL 300
            ..|.||:..:|               .||..:| ||.::.::.:|.:..:.:.|.||....|...
Mouse   239 LAIRAVAKQQK---------------ESESTQK-AEKEVTRMVVVMVFAYCLCWGPYTFFACFAT 287

  Fly   301 ----FKFEGLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALKEKCPCCVFG-KVDDGKSSDA 360
                :.|.   ||.....:.|||||..||||:|...:.::|     .|...:|| ||||.....:
Mouse   288 AHPGYAFH---PLVASLPSYFAKSATIYNPIIYVFMNRQFR-----NCILHLFGKKVDDSSELSS 344

  Fly   361 QSQATASEAES 371
            .|:...|...|
Mouse   345 TSKTEVSSVSS 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	90/297 (30%)
		TM helix 1	53..77	CDD:320207	8/24 (33%)
		TM helix 2	86..108	CDD:320207	6/21 (29%)
		TM helix 3	124..146	CDD:320207	6/21 (29%)
		TM helix 4	168..184	CDD:320207	4/15 (27%)
		TM helix 5	212..235	CDD:320207	7/25 (28%)
		TM helix 6	275..297	CDD:320207	4/21 (19%)
		TM helix 7	308..333	CDD:320207	12/24 (50%)
Opn1mw	NP_032132.1	Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	12..38
Opn1mw	NP_032132.1	7tm_1	66..317	CDD:278431	83/269 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6735
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860