DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ninaE and tmtops2b

DIOPT Version :9

Sequence 1:	NP_524407.1	Gene:	ninaE / 42367	FlyBaseID:	FBgn0002940	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001269302.1	Gene:	tmtops2b / 100331536	ZFINID:	ZDB-GENE-110411-43	Length:	368	Species:	Danio rerio

Alignment Length:	347	Identity:	95/347 - (27%)
Similarity:	159/347 - (45%)	Gaps:	50/347 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DMAHLISPYWNQFPAMDPIWAKILTAYMIMIGMISWCG---NGVVIYIFATTKSLRTPANLLVIN 91
            |...|:...|:..| |:.:......|..:.:|.|...|   |.||:.:|...|:||||.|:|::|
Zfish     5 DRLTLLDEDWSDSP-METLSRAGFIALSVFLGFIMTFGFFNNLVVLVLFCKFKTLRTPVNMLLLN 68

  Fly    92 LAISDFGIMITNTPMMGINLYFET-----WVLGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQV 151
            ::|||..:.     |.|..|.|.:     |:||...|..|..:.|.||..|:.|:.::|.|||..
Zfish    69 ISISDMLVC-----MFGTTLSFASSVRGRWLLGRHGCMWYGFINSCFGIVSLISLVVLSYDRYST 128

  Fly   152 IV---KGMAG--RPMTIPLALGKIAYIWFMSSIWCLAPAFGWSRYVPEGNLTSCGIDYLERDWNP 211
            :.   |....  :|:   ||:|.   .|..|.||.:.|..|||.|..||..|||.:.:.:|....
Zfish   129 LTVYHKRAPDYRKPL---LAVGG---SWLYSLIWTVPPLLGWSSYGLEGAGTSCSVSWTQRTAES 187

  Fly   212 RSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKAMREQAKKMNVKSLRSSEDAEKSAEGKLAK 276
            .:|:|...:|...:|:.::.|.|..::.||....|..:..|:|               .|..:..
Zfish   188 HAYIICLFVFCLGLPVLVMVYCYGRLLYAVKQVGKIRKTAARK---------------REYHVLF 237

  Fly   277 VALVTITLWFMAWTPYLVINCMGLFKFEG-LTPLNTIWGACFAKSAACYNPIVYGISHPK----Y 336
            :.:.|:..:.:.|.||.|:..|..|...| ::|:.::..:..|||:...||::|.:.:.:    :
Zfish   238 MVITTVVCYLLCWMPYGVVAMMATFGRPGIISPVASVVPSLLAKSSTVINPLIYILMNKQFYRCF 302

  Fly   337 RLALKEKCPCCVFGKVDDGKSS 358
            |:..     ||....:.:|.||
Zfish   303 RILF-----CCQRSLLQNGHSS 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ninaE	NP_524407.1	7tmA_photoreceptors_insect	52..340	CDD:320207	85/305 (28%)
		TM helix 1	53..77	CDD:320207	8/26 (31%)
		TM helix 2	86..108	CDD:320207	7/21 (33%)
		TM helix 3	124..146	CDD:320207	6/21 (29%)
		TM helix 4	168..184	CDD:320207	5/15 (33%)
		TM helix 5	212..235	CDD:320207	5/22 (23%)
		TM helix 6	275..297	CDD:320207	5/21 (24%)
		TM helix 7	308..333	CDD:320207	7/24 (29%)
tmtops2b	NP_001269302.1	7tm_4	36..>78	CDD:304433	17/46 (37%)
		7tm_1	45..291	CDD:278431	79/271 (29%)
		ALDH-SF	215..>288	CDD:299846	18/87 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910