DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ask1 and MAP3K6

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	NP_004663.3	Gene:	MAP3K6 / 9064	HGNCID:	6858	Length:	1288	Species:	Homo sapiens

Alignment Length:	1382	Identity:	489/1382 - (35%)
Similarity:	694/1382 - (50%)	Gaps:	208/1382 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVVCVMDTAVGDHLEDRQ----------CALEEIKQAVQ-SAGANFQRVQFERLDFGETNVLET 54
            :.||.|:.......||.|:          |..|...|..: ......:.:.|..|:.|:|..|:.
Human    45 LSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDA 109

  Fly    55 FYNADVAIIDLSILTQQRPLSYHYGVRESFGMKENILTYNDIDSKQTLSLK-------LSC-ANY 111
            ||||||.::::|....|..|.||.||||||.|..|:|..:..|.....:|:       ..| .:|
Human   110 FYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALREDVFQKNSDCVGSY 174

  Fly   112 LFLSYKRNAE----TNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRKLQDVEIQSKAHMREKF 172
            ..:.|...|.    .....|......|........|..:..|..||.|.|:.....|..:.||..
Human   175 TLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVGRLARLLEATPTDSCGYFRETI 239

  Fly   173 LSDMRTARDTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKN 237
            ..|:|.||:.:  :|.:|:..|..:::|||...:||.:::.:.:.|.||||||.|::.||..|:.
Human   240 RRDIRQARERF--SGPQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQA 302

  Fly   238 IPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVE 302
            :| |....|..|:.|.|.||||||||.|||.|||...|..::.:.:..||:.|:|||||||:|..
Human   303 LP-TCDVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFS 366

  Fly   303 SDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGS 367
            |.:.||.....|..|||::|:|:|:.::|||.|.||:..|:.|.:::||:.|||.|..|:.:||.
Human   367 SGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGC 431

  Fly   368 LSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQP 432
            :..:..||||..:....:||||..:.:.|||.::||..|.|||.|.:....|...||..||....
Human   432 VEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGG 496

  Fly   433 PIEEQVFQFWMDFFLEATNTEEVKNSI----RFPILILEPQKIYMPSYV---------TINMDAD 484
            |....  .||:.|.|:  :.:..|.:.    :..:|:||..|:.:|:.:         |:.:...
Human   497 PPRRA--HFWLHFLLQ--SCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLL 557

  Fly   485 EKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPSTERR 549
            |...|.:.             ..:.|..:.|..||..|||:||.:||....:.|.|:.|||....
Human   558 EPETQDIP-------------SSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHC 609

  Fly   550 QKFYDMILEMTADQVVFVNLSNDDAN------------IEYEYDYDEQNRKMVLGKGTYGTVYAA 602
            |.|..:|...         ::|.|:.            :|::|:|.|...::||||||||.|||.
Human   610 QWFCGLIQAW---------VTNPDSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAG 665

  Fly   603 RDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSL 667
            ||:.|:|||||||:||::|:..|||||||.||.:|||:||||||||.|:.|:.|||||:||||||
Human   666 RDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSL 730

  Fly   668 SDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSK 732
            |.||.:.||||||||||::||::|||:||.|||:..||||||||||||:||:||::|||||||||
Human   731 SSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSK 795

  Fly   733 RLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMF 797
            |||.|.|.||||||||||||||:||||.||||.||||||.|||.:|||||:|||.||||..||||
Human   796 RLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMF 860

  Fly   798 KVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPINTEFGR 862
            :||.||.||.:|..|||.|:.|:||.|......|.||..||.|||||...|...|:.|      |
Human   861 QVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRSPSSP------R 919

  Fly   863 SISVPADRFVHKTTPPLSYNTTCNTPTTPELDITH-------------SSSVDIDELPSNQFMLE 914
            ....|:|......||..:..|...|...|:....|             :|.:.:.|.|:.:
Human   920 HAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLRVPEEPAAE---- 980

  Fly   915 RRNSHGFLLSPEIEPSTPSLRTSISETSETDGFYRLKKDSQRRTTLSKVL-----ALDESKICDI 974
                         ||::|         .|:.|...|.::|:||..|:.||     ||.|:
Human   981 -------------EPASP---------EESSGLSLLHQESKRRAMLAAVLEQELPALAEN----- 1018

  Fly   975 WLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQKLNNDAVALDHLHLALYS 1039
             |.:....:....:.::.:|.|:|.|..:|...|.:.|...:..|:.:|....:....||..|::
Human  1019 -LHQEQKQEQGARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFA 1082

  Fly  1040 FQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQK 1104
            |.|||..:||...|:|||||.||:|:.|||:||:.:..||:     :|:......|.|      .
Human  1083 FPDAVKQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEV-----EKEAVSPRSEEL------S 1136

  Fly  1105 GSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDALSSSMECARI----LRDIRDNQQKLQRQLL 1165
            ...:||:....:..||..          .|.|...|...:...|.    ||:|...:::
Human  1137 NEGDSQQSPGQQSPLPVE----------PEQGPAPLMVQLSLLRAETDRLREILAGKER------ 1185

  Fly  1166 EQQRQSMRALHNISQELAHIYMGGRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLN 1230
            |.|....|||..:::| |..|:                                 :|..|...|:
Human  1186 EYQALVQRALQRLNEE-ARTYV---------------------------------LAPEPPTALS 1216

  Fly  1231 KHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKL 1295
                    .|:.|.|||.:..:|..:..::||..||....:....:.||:...:|.|:..|:|:.
Human  1217 --------TDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRIRGGMVCRIWRA 1273

  Fly  1296 IIQERVCTSSDCVDSPP 1312
            |:.:|  ..|..|.|.|
Human  1274 ILAQR--AGSTPVTSGP 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020	137/381 (36%)
		STKc_ASK	576..843	CDD:270794	183/266 (69%)
		S_TKc	590..843	CDD:214567	179/252 (71%)
MAP3K6	NP_004663.3	DUF4071	129..506	CDD:290020	137/381 (36%)
		STKc_ASK	639..906	CDD:270794	183/266 (69%)
		S_TKc	653..906	CDD:214567	179/252 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..997		28/129 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1123..1157		7/54 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157774
Domainoid	1	1.000	385	1.000	Domainoid score	I815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122434at33208
OrthoFinder	1	1.000	-	-		FOG0001687
OrthoInspector	1	1.000	-	-		otm40380
orthoMCL	1	0.900	-	-		OOG6_104013
Panther	1	1.100	-	-	O	PTHR11584
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1591
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.850