Protein Alignment Ask1 and NP1

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_563832.2
• Gene: NP1 / 837421
• AraportID: AT1G09000
• Length: 666
• Species: Arabidopsis thaliana
• Alignment Length: 648
• Identity: 200/648 - (30%)
• Similarity: 307/648 - (47%)
• Gaps: 149/648 - (22%)

  Fly   590 VLGKGTYGTVYAARDKQTQVRIAIKEV--------PEKNSQDVQPLHEEIKLHSQLRHRNIVRYL 646
            ::|:|.:||||...:..:...:|:|:|        .||....:|.|.||:||...|.|.||||||
plant    74 LIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYL 138

  Fly   647 GSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKG 711
            |:..|:....|.:|.|||||:|.||| |:||..  ||.:..|::|:|.||:|||...|:||||||
plant   139 GTVREDDTLNILLEFVPGGSISSLLE-KFGPFP--ESVVRTYTRQLLLGLEYLHNHAIMHRDIKG 200

  Fly   712 DNVLVNTYSGVVKISDFGTSKRLARINPMT--ETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGC 774
            .|:||:. .|.:|::|||.||::|.:..||  ::..||..:||||||.|  .|:..:|||||.||
plant   201 ANILVDN-KGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQ--TGHSFSADIWSVGC 262

  Fly   775 TNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLE 839
            |.:||.|||.|:.:.....||:|.:|..|.||.||:.||::||:|:|:|.......||:||:||:
plant   263 TVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLK 327

  Fly   840 DPFLQDKPRKVRPALPINTEFGRSISVPADRFVHKTTP-PLSYNTTCNTP--TTPEL-DITHSSS 900
            .||:..|.::     ..:|:.|..::       :.:|| ||..|.|.:||  |..:: |:.:..|
plant   328 HPFVMGKHKE-----SASTDLGSVLN-------NLSTPLPLQINNTKSTPDSTCDDVGDMCNFGS 380

  Fly   901 VD---IDELPSNQFM-LERRNSHG------FLLSPEIEPSTPSLRTSISETSETDGFYRLKKDSQ 955
            ::   :|.:.|.|.. |.::|.:|      .|:..|      :..|...|.|.|     |:||..
plant   381 LNYSLVDPVKSIQNKNLWQQNDNGGDEDDMCLIDDE------NFLTFDGEMSST-----LEKDCH 434

  Fly   956 RRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIM-------NENEKHLE 1013
            .:            |.||      |....|||::....|....|.::..|       :.:|...|
plant   435 LK------------KSCD------DISDMSIALKSKFDESPGNGEKESTMSMECDQPSYSEDDDE 481

  Fly  1014 ATINELKQKLNNDAVALDHLHLALY-SFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFS 1077
            .|.:::|..|:..|..|..|...|| .|.::::                             .||
plant   482 LTESKIKAFLDEKAADLKKLQTPLYEEFYNSLI-----------------------------TFS 517

  Fly  1078 PE-LGANLADKDLSGNDD----------ESLRTSLMQKGSTESQ--EKQSLEKVLPTSNTREGVG 1129
            |. :.:||::   |..:|          :|...|....|.:.|:  :..|..|...:..:||
plant   518 PSCMESNLSN---SKREDTARGFLKLPPKSRSPSRGPLGGSPSRATDATSCSKSPGSGGSRE--- 576

  Fly  1130 LTPAESGGDALSSSMECARILRDIR----DNQQKLQR----------------QLLEQQRQSM 1172
             ....:|||..|.....||: .|.|    |.:|:|.:                |.||::||.:
plant   577 -LNINNGGDEASQDGVSARV-TDWRGLVVDTKQELSQCVALSEIEKKWKEELDQELERKRQEI 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459
		MAP3K_TRAF_bd	74..445	CDD:463827
		ASK_PH	457..560	CDD:465956
		STKc_ASK	576..843	CDD:270794	118/262 (45%)
		HisK-N-like	948..1079	CDD:466452	26/138 (19%)
NP1	NP_563832.2	STKc_MAPKKK	68..331	CDD:270783	118/262 (45%)